Browse the latest research summaries in the field of brain injury for spinal cord injury patients and caregivers.
Showing 71-80 of 128 results
Arch Phys Med Rehabil, 2015 • January 1, 2015
This study aimed to identify aspects of HRQOL relevant to caregivers of individuals with TBI and propose an integrated conceptual framework. Nine focus groups with caregivers of individuals with moder...
KEY FINDING: Caregivers' social health was the most frequently identified area of concern, encompassing community life, role changes, and finances.
Top Spinal Cord Inj Rehabil, 2014 • July 1, 2014
This study aimed to evaluate medical, psychological, functional, and community outcomes of adults with dual diagnosis (SCI and TBI) compared to those with single diagnosis of SCI or TBI. The findings ...
KEY FINDING: Individuals with dual diagnosis (SCI and TBI) showed similar functional outcomes to those with SCI alone at rehabilitation discharge.
Neurobiol Dis., 2015 • February 1, 2015
The study investigated the role of neutrophil elastase (NE) in acute and chronic outcomes after traumatic brain injury (TBI) in the developing brain of mice. Results showed that NE contributes to acut...
KEY FINDING: Genetic deletion or inhibition of NE results in alleviation of acute cell death, strongly implicating NE in early post-injury pathogenesis.
Clinical Neuropharmacology, 2016 • November 1, 2016
Traumatic brain injury (TBI) is an alteration in brain function, caused by an external force...Traumatic brain injury is a major cause of morbidity and mortality worldwide. Baclofen is a muscle relaxa...
KEY FINDING: Spasticity in TBI is estimated to be between 17% and 50% of patients with moderate to severe TBI that presents increased muscle tone or spasticity.
Exp Neurol, 2015 • March 1, 2015
This study investigates the association of microRNAs (miRNAs) with hippocampal mitochondria and changes in their expression following controlled cortical impact (CCI) injury in rats. The findings demo...
KEY FINDING: The miRNA processing proteins Argonaute (AGO) and Dicer are present in mitochondria fractions from uninjured rat hippocampus, suggesting functional RNA-induced silencing complexes are present.
J Bioenerg Biomembr, 2016 • April 1, 2016
The review focuses on the role of lipid peroxidation (LP) in the secondary injury process following traumatic brain injury (TBI) or spinal cord injury (SCI). Mitochondrial dysfunction, triggered by ox...
KEY FINDING: Mitochondria are a crucial source and target of oxidative stress and damage in the injured central nervous system.
Handb Clin Neurol, 2015 • January 1, 2015
Autonomic dysfunction can occur after traumatic brain injury due to damage to the central autonomic network (CAN), affecting the balance of excitatory and inhibitory inputs to ANS effector organs. Isc...
KEY FINDING: Ischemic strokes, especially insular strokes, may cause cardiac autonomic dysregulation, potentially leading to subendocardial hemorrhages and myocardial infarction.
International Journal of Environmental Research and Public Health, 2015 • April 14, 2015
This study compared function and disability in TBI and SCI patients using the WHODAS 2.0, analyzing data from Taiwan’s national disability registry between September 2012 and August 2013. The findings...
KEY FINDING: Patients with TBI exhibited poorer cognition, self-care, relationships, life activities, and participation in society compared to those with SCI.
Neuroscience, 2015 • July 9, 2015
The study examined the effects of mild traumatic brain injury (TBI) on motor function and neuropathology in wild-type mice and a transgenic model of ALS (G93A mutant mice). Mild-TBI induced inflammati...
KEY FINDING: Mild TBI in mice resulted in impaired rotarod performance, indicating motor coordination deficits, and reduced grip strength, suggesting muscle weakness.
Frontiers in Human Neuroscience, 2011 • November 23, 2011
This study investigated the impact of a combined robotic and cognitive gait rehabilitation (RCGR) protocol on cerebral functional reorganization in two chronic traumatic brain injury (TBI) patients wi...
KEY FINDING: Greater activation post-training was observed in the sensorimotor and supplementary motor cortices.