Browse the latest research summaries in the field of cardiovascular science for spinal cord injury patients and caregivers.
Showing 241-250 of 309 results
Journal of Visualized Experiments, 2015 • July 16, 2015
This study introduces a photothrombotic model of spinal cord ischemia in mice. The method involves inducing ischemia by injecting Rose Bengal and irradiating the spinal cord with green light. The resu...
KEY FINDING: Photothrombosis effectively induced spinal cord infarction in mice.
Frontiers in Molecular Biosciences, 2023 • June 30, 2023
This study investigated platelet activation, proteome, and transcriptome in Alzheimer’s disease (AD) patients, non-demented elderly, and young individuals to understand the molecular mechanisms underl...
KEY FINDING: AD and aged individuals had a proteomic signature suggestive of increased platelet activation compared with young controls.
Arch Phys Med Rehabil, 2013 • September 1, 2013
This study aimed to identify medically relevant aspects of blood pressure dysregulation (BPD) related to quality of life in individuals with spinal cord injury (SCI) and propose an integrated conceptu...
KEY FINDING: The most frequent topic discussed in focus groups was symptoms of BPD, followed by precipitators/causes, preventative actions, corrective actions, and impact on social/emotional functioning.
The Journal of Spinal Cord Medicine, 2021 • January 1, 2021
This systematic review assessed the effect of dietary interventions on cardiovascular disease (CVD) risk in adults with spinal cord injury (SCI). Eight studies were included, revealing variations in d...
KEY FINDING: Dietary interventions, especially when combined with exercise, showed potential in improving cardiovascular disease risk markers in individuals with SCI.
Cellular and Molecular Life Sciences, 2024 • February 18, 2024
This study investigates the role of the deubiquitinase UCHL1 in promoting angiogenesis and blood-spinal cord barrier (BSCB) function recovery after spinal cord injury (SCI) by stabilizing Sox17. The f...
KEY FINDING: Sox17 is predominantly localized in endothelial cells and is significantly upregulated after SCI and in LPS-treated brain microvascular endothelial cells.
J. Phys. Ther. Sci., 2016 • July 1, 2016
The study investigated the cardiovascular autonomic response during recovery after handcycle training in quadriplegics with spinal cord injury (SCI) compared to healthy subjects. Both groups showed a ...
KEY FINDING: Quadriplegics (SCIG) showed reduced heart rate variability (HRV) parameters (RR, SDNN, rMSSD, LF, HF, SD1, and SD2) after handcycle training, with SDNN, LF, and SD2 remaining decreased during recovery.
International Journal of Molecular Sciences, 2019 • May 18, 2019
This review examines the impact of extreme blood pressure lability on vascular cognitive impairment (VCI) in individuals with spinal cord injury (SCI). It highlights the potential mechanisms by which ...
KEY FINDING: Individuals with SCI experience significant cardiovascular impairments, including drastic blood pressure fluctuations, which can lead to vascular cognitive impairment.
Photoacoustics, 2021 • March 10, 2021
This study introduces a new method, PA-PAS, for evaluating microvessel structures by mapping the acoustic power spectrum of photoacoustic signals along the azimuth direction. The method calculates the...
KEY FINDING: The intensity of photoacoustic signals from microvessels varies depending on the direction of measurement, with the strongest signals observed in the direction of the vessel's width.
The Journal of Spinal Cord Medicine, 2019 • September 1, 2019
This pilot study aimed to determine if intermittent pneumatic compression (IPC) could increase leg blood flow and enhance vascular endothelial function in individuals with spinal cord injury (SCI). Th...
KEY FINDING: Peak shear rate in the experimental leg increased significantly at 15 minutes during IPC (215±137 to 285±164 s−1 at 15 mins; +39±29%, P = 0.03), while no change occurred in the control leg.
Stem Cell Research & Therapy, 2021 • February 2, 2021
The study investigates the therapeutic potential of myogenic progenitor cells (MPCs) for muscle regeneration following ischemia/reperfusion injury (IRI) in a murine hindlimb model. Results showed that...
KEY FINDING: WIT-induced IRI in muscle requests increased numbers of injected MPC to engraft and persist, suggesting a possible rational for cell therapy to antagonize IRI.