Browse the latest research summaries in the field of cardiovascular science for spinal cord injury patients and caregivers.
Showing 301-309 of 309 results
Frontiers in Neuroanatomy, 2023 • March 21, 2023
This study quantified structural changes in capillary morphology and microstructure from the acute to chronic stages of SCI, providing insights into the microvascular pathology and potential targets f...
KEY FINDING: Acute microvascular disruption was evident post-SCI, particularly at the injury epicentre, spreading three spinal segments rostrally and caudally.
Brain and Spine, 2025 • January 23, 2025
This study comprehensively examines the temporospatial dynamics of vascular injury and regeneration following experimental spinal cord injury (SCI) in mice, focusing on changes in vascular density, pe...
KEY FINDING: Vascular injury is most severe initially at the epicenter and spreads to surrounding spinal cord regions, with a delayed vascular loss observed in peritraumatic regions.
Eur J Neurosci, 2009 • January 1, 2009
This study investigated whether a coculture of endothelial cells (ECs) and neural progenitor cells (NPCs) in a biodegradable implant could promote angiogenesis and formation of the blood-spinal cord b...
KEY FINDING: The coculture implant led to a four fold increase in functional vessels compared to the lesion control, implant alone, or implant plus NPCs groups.
Neural Regen Res, 2018 • May 1, 2018
This study demonstrates that endothelial progenitor cell-conditioned medium (EPC-CM) exerts anti-inflammatory effects, promotes angiogenesis, and provides neuroprotection in a rat model of spinal cord...
KEY FINDING: EPC-CM reduces inflammation by decreasing M1 macrophage activation and the release of pro-inflammatory cytokines.
J Spinal Cord Med, 2009 • April 1, 2009
This case report describes a patient with chronic SCI who presented with severe fatigue and was diagnosed with severe dilated cardiomyopathy. The patient's multiple risk factors, including obesity, sm...
KEY FINDING: The patient had a 2-year history of progressive severe fatigue, obesity, hypertension, tachycardia, and pitting edema.
Cureus, 2022 • May 30, 2022
Spinal cord injuries (SCI) initiate a complex pathological process, necessitating a comprehensive understanding of intrinsic procedures for ensuring optimal treatment and recovery conditions. Vascular...
KEY FINDING: Endogenous angiogenesis, while triggered by SCI and ischemia, is frequently inadequate to address the progressive local ischemia and cell death.
Biomech Model Mechanobiol, 2012 • January 1, 2012
This study examined the impact of mechanical strain and TGF-β1 on urinary bladder wall smooth muscle remodeling using an ex vivo organ culture system. Results showed that a 0.5-Hz strain induced elast...
KEY FINDING: A 0.5-Hz strain frequency triangular waveform stimulation at 15% strain resulted in fibrillar elastin production, collagen turnover, and a more compliant ECM.
Advanced Science, 2024 • September 28, 2024
This study demonstrates that traumatic pathological vascular remodeling occurs during the chronic phase of injury, characterized by enlarged vessel diameter, disruption of blood-spinal cord barrier, e...
KEY FINDING: Traumatic SCI leads to pathological vascular remodeling, including enlarged vessel diameter and disruption of the blood-spinal cord barrier.
Nature Communications, 2017 • January 10, 2017
The study elucidates how developing zebrafish spinal cord neurons coordinate vessel growth by balancing neuron-derived Vegfaa and sFlt1, which restricts angiogenesis at the neurovascular interface. Lo...
KEY FINDING: Neuronal sFlt1 restricts angiogenesis around the spinal cord by limiting Vegfaa availability.