Browse the latest research summaries in the field of cardiovascular science for spinal cord injury patients and caregivers.
Showing 231-240 of 309 results
J Neurosurg Spine, 2009 • October 1, 2009
This study examines surgical methods to reduce scar and cyst formation in complete transection SCI models in rats, focusing on the influence of vasculature disruption. Dural closure with sutures signi...
KEY FINDING: Dural closure using sutures resulted in significantly less glial scar formation compared to leaving the dura open.
Lipids in Health and Disease, 2015 • July 22, 2015
This study investigated the lipoprotein profiles of individuals with spinal cord injury (SCI) using nuclear magnetic resonance (NMR) spectroscopy to assess cardiovascular disease (CVD) risk. It compar...
KEY FINDING: Individuals with SCI and normal HDL-C had negligible differences in lipoprotein particle profile compared to able-bodied individuals, except for fewer number and smaller size of HDL-P.
The Journal of Spinal Cord Medicine, 2012 • January 1, 2012
The study evaluated the test–retest reliability of aortic PWV, leg PWV and arm PWV in people with chronic SCI. Aortic PWV and leg PWV had almost perfect test–retest reliability. The test–retest reliab...
KEY FINDING: Aortic and leg PWV measurements showed high test–retest reliability in individuals with chronic SCI.
Neural Regen Res, 2024 • August 1, 2024
Neutrophil extracellular traps are primarily composed of DNA and histones and are released by neutrophils to promote inflammation and thrombosis when stimulated by various inflammatory reactions. Neur...
KEY FINDING: NETs are key mediators of inflammation and thrombosis, and have been widely accepted as a mechanism of deep vein thrombosis.
Journal of Nanobiotechnology, 2024 • August 22, 2024
This study investigates the role of spinal cord-derived microvascular endothelial cells (SCMECs) in promoting axon growth after spinal cord injury (SCI). The researchers found that SCMECs promote axon...
KEY FINDING: SCMECs promote axon outgrowth in a non-contact fashion by downregulating miR-323-5p expression in neurons.
Angiogenesis, 2018 • May 1, 2018
This study investigates the impact of chronic mild hypoxia (CMH) on vascular remodeling in the spinal cord, revealing that CMH promotes endothelial proliferation, angiogenesis, and arteriogenesis. The...
KEY FINDING: Chronic mild hypoxia (CMH) promotes endothelial proliferation and increased vascularity in spinal cord blood vessels through angiogenesis and arteriogenesis.
ASN NEURO, 2013 • August 7, 2013
This study demonstrates neuroendocrine signaling peptide alterations, associated with central inflammation and metabolic dysfunction post-SCI. The research provides evidence for the peripheral activat...
KEY FINDING: Chronic SCI results in decreased POMC and increased NPY expression in the hypothalamic ARC and PVN.
Circ Res, 2015 • June 5, 2015
The autonomic nervous system intricately modulates nearly all physiological functions of the heart. Cardiac autonomic dysregulation is central to the development and progression of most cardiovascular...
KEY FINDING: Cardiac injury leads to abnormal signaling in the nervous system, resulting in excessive sympathetic activity and potentially fatal arrhythmias.
PLoS ONE, 2016 • May 13, 2016
The study investigates the potential extra-cardiac growth effects of rNRG1 in mice, complementing a prior presentation of a therapeutic strategy for rNRG1 administration in pediatric patients. Results...
KEY FINDING: Administration of rNRG1 did not alter somatic growth, as measured by body weight and tibia length.
Inflammation and Regeneration, 2022 • September 2, 2022
This study investigates the mechanism of pericyte-fibroblast transition after spinal cord injury (SCI) and the role of the PDGF-BB/PDGFRβ signaling pathway in this process. The results show that micro...
KEY FINDING: PDGFRβ+ pericytes detach from blood vessel walls and transition into fibroblasts to form fibrotic scar after SCI, indicating a key role in scar formation.