Browse the latest research summaries in the field of cardiovascular science for spinal cord injury patients and caregivers.
Showing 261-270 of 309 results
Journal of Neurochemistry, 2025 • February 3, 2025
The study introduces a novel tamoxifen-inducible PDGFRβ+ cell ablation model in mice to investigate pericyte responses in the CNS following acute ablation, addressing limitations in existing models. T...
KEY FINDING: A low dose of tamoxifen effectively ablates PDGFRβ+ cells of the CNS in mice without reducing survival or causing significant systemic side effects, such as weight loss.
Journal of Cerebral Blood Flow & Metabolism, 2012 • August 1, 2012
This study investigates the role of pericytes in the blood–spinal cord barrier (BSCB). It demonstrates that pericyte coverage and number are reduced in spinal cord capillaries compared to the brain, p...
KEY FINDING: Spinal cord capillaries, especially in the anterior horn, have fewer pericytes compared to brain capillaries in wild-type mice.
Journal of Medicine and Life, 2009 • April 1, 2009
Cardiac dysfunctions are common consequences following SCI, and cardiovascular disturbances are the leading causes of morbidity and mortality in both acute and chronic phases. SCI disrupts pathways fr...
KEY FINDING: SCI associates significant cardiac dysfunction, particularly in patients with cervical or high thoracic injuries, leading to arrhythmias like bradycardia and hypotension.
The Journal of Spinal Cord Medicine, 2018 • November 1, 2018
This case report highlights a fatal case of innominate artery hemorrhage in a patient with tetraplegia and a tracheostomy, emphasizing the importance of recognizing and managing this rare but lethal c...
KEY FINDING: A 'sentinel bleed' or 'herald bleed' can be an early warning sign of a trachea-innominate artery fistula (TIF). This bleeding may be self-limiting but recurrent, and can be aggravated by coughing or aspiration.
Neural Regeneration Research, 2014 • December 1, 2014
Melatonin has been shown to diminish edema in rats. This study presumed that melatonin could relieve spinal cord edema and examined how it might act. Our experiments found that melatonin (100 mg/kg, i...
KEY FINDING: Melatonin (100 mg/kg, i.p.) could reduce the water content of the spinal cord after spinal cord injury.
Medicine, 2017 • October 20, 2017
This case report describes a patient with cervical spinal cord injury who presented with neck-to-shoulder pain, which was later diagnosed as pulmonary embolism. The patient's pain was initially though...
KEY FINDING: Neck-to-shoulder pain can be an atypical symptom of pulmonary embolism, especially in patients with cervical spinal cord injury.
The Journal of Spinal Cord Medicine, 2011 • January 1, 2011
This study compared rehabilitation outcomes between vascular-related spinal cord injury (VR-SCI) and traumatic spinal cord injury (T-SCI) patients. VR-SCI patients tend to be older and have different ...
KEY FINDING: Patients with VR-SCI were generally older and more likely to have paraplegia compared to those with T-SCI. Common causes of VR-SCI included post-surgical complications, arteriovenous malformations, and aortic dissection.
The Journal of Spinal Cord Medicine, 2017 • January 1, 2017
This pilot study evaluated the therapeutic potential of passive standing with whole body vibration (PS-WBV) on arterial stiffness among men with chronic spinal cord injury (SCI). Fifteen individuals w...
KEY FINDING: Forty weeks of passive standing with whole body vibration (PS-WBV) did not result in observable changes in aortic or leg pulse wave velocity (PWV) in men with chronic SCI.
Frontiers in Neurology, 2019 • March 26, 2019
This study demonstrates the feasibility of using functional ultrasound (fUS) imaging to monitor spinal cord hemodynamic responses to epidural electrical stimulation (SCS) in animal models. The researc...
KEY FINDING: fUS can detect spinal cord hemodynamic responses to epidural electrical stimulation (SCS) in both rat and swine models.
PLoS ONE, 2015 • February 23, 2015
The study examined serum lipid concentrations in subjects with traumatic SCI in relation to the degree of neurological involvement and time since injury, comparing them with values from a reference sa...
KEY FINDING: Cases without preserved motor function (AIS A or B) had lower total and HDL cholesterol than the others.