Browse the latest research summaries in the field of endocrinology for spinal cord injury patients and caregivers.
Showing 51-60 of 211 results
Turk J Phys Med Rehab, 2022 • March 1, 2022
This study investigated the effects of spasticity on glucose metabolism and body composition in patients with spinal cord injury (SCI). The results suggest that spasticity has positive effects on fat-...
KEY FINDING: In patients with motor complete SCI, a positive correlation was found between hip adductor muscle spasticity and trunk, android, and gynoid fat-free mass percentages.
Frontiers in Endocrinology, 2022 • August 5, 2022
This study evaluated the differential expression of miRNAs in subjects with chronic SCI, acute SCI, and no SCI to investigate the association of these miRNAs with SCI mediated osteoporosis and related...
KEY FINDING: MiR-148a-3p was upregulated in subjects with acute SCI vs chronic SCI, as well as in acute SCI vs no SCI.
The Journal of Spinal Cord Medicine, 2022 • January 1, 2022
This study investigated the relationships between body composition (%FM, %LM, and %FM to %LM ratio), inflammatory markers, and metabolic syndrome in individuals with chronic SCI. The results showed th...
KEY FINDING: Both higher %FM and lower %LM were associated with markers of inflammation (hs-CRP) and metabolic syndrome.
JOURNAL OF NEUROTRAUMA, 2019 • December 15, 2019
The study assessed factors associated with circulating BAFF in non-ambulatory males with chronic SCI, finding that active smokers had significantly greater BAFF levels than former/nonsmokers. The rese...
KEY FINDING: Active smokers had significantly greater BAFF levels than former/nonsmokers (871 pg/mL vs. 665 pg/ml, p = 0.002).
Physiological Reports, 2019 • October 1, 2019
This study compared the effects of abaloparatide and teriparatide on bone structure, turnover, and signaling pathways in mice and cells. The results showed that abaloparatide had a greater osteoanabol...
KEY FINDING: Abaloparatide caused a greater dose-dependent increase in cortical thickness than teriparatide.
J Neurosci Res, 2020 • May 1, 2020
The study assessed the effects of treadmill training (TM) and testosterone-enanthate (TE) on musculoskeletal recovery in rats after severe spinal cord injury (SCI). Short-term TM alone did not improve...
KEY FINDING: Treadmill training alone did not improve bone, muscle, or locomotor recovery after severe SCI in rats.
Spinal Cord Series and Cases, 2019 • October 31, 2019
The article discusses the recently published guidelines for identification and management of cardiometabolic risks after spinal cord injury (SCI). It highlights the inappropriateness of applying gener...
KEY FINDING: Inappropriate application of obesity definitions for the general population to individuals with SCI.
Frontiers in Endocrinology, 2020 • April 15, 2020
This review comprehensively characterizes available treatment options targeting the skeleton and bone in the setting of SCI. Pharmacological interventions such as bisphosphonates and anti-sclerostin m...
KEY FINDING: Bisphosphonates, anti-sclerostin monoclonal antibodies, hydrogen sulfide, parathyroid hormone, and RANKL pathway inhibitors are valuable options for treating bone alterations after SCI.
Neurobiol Dis, 2020 • July 1, 2020
This study investigates the impact of a Western diet on the adult mouse spinal cord and its response to traumatic injury. Findings show that systemic insulin resistance is reflected in abnormalities i...
KEY FINDING: A Western diet impairs insulin signaling and energy homeostasis in the spinal cord, even before injury.
AACE Clinical Case Reports, 2020 • May 1, 2020
This case report describes a type 1 diabetic patient who developed tetraplegia and experienced a massive increase in subcutaneous insulin requirements. Treatment with pramlintide led to a significant ...
KEY FINDING: The patient's subcutaneous insulin requirements increased dramatically to 600 U/day after spinal cord injury, compared to 81 U/day before the injury.