Browse the latest research summaries in the field of gastroenterology for spinal cord injury patients and caregivers.
Showing 61-70 of 138 results
Frontiers in Rehabilitation Sciences, 2022 • October 26, 2022
This study measured the gut microbiome in the first three weeks of rehabilitation following stroke and its associations with leaky gut markers, dietary intake, and functional recovery measures. The re...
KEY FINDING: Stroke patients had significantly lower abundances of butyrate producers, secondary bile acid producers, equol producers, and sulfate reducers in their gut.
Molecular Brain, 2023 • February 5, 2023
This study examined the gut microbiota and serum metabolites in SCI patients compared to healthy individuals to understand their interaction in SCI pathogenesis. We present a comprehensive landscape o...
KEY FINDING: SCI patients have different gut bacteria compared to healthy people, with increases in some bacteria (UBA1819, Anaerostignum, Eggerthella, Enterococcus) and decreases in others (Faecalibacterium, Blautia, Escherichia–Shigella, Agathobacter, Collinsella, Dorea, Ruminococcus, Fusicatenibacter, and Eubacterium).
Spinal Cord, 2020 • January 27, 2020
This study introduces and validates the MENTOR tool, designed to monitor the effectiveness of neurogenic bowel dysfunction (NBD) treatment in individuals with spinal cord injury (SCI). The MENTOR tool...
KEY FINDING: The MENTOR tool shows good agreement with expert clinicians in identifying patients who need a change in bowel management.
Frontiers in Microbiology, 2022 • September 26, 2022
This study aimed to investigate the changes in lymphocyte subsets and gut microbiota in Chinese Han patients with SCI. It enrolled 23 SCI patients and 21 healthy controls, collecting blood and fecal s...
KEY FINDING: CD4 + cells, CD4 + /CD8 + ratio and CD4 + CD8 + cells in peripheral blood of SCI patients were significantly lower than those of the control group.
Spinal Cord Series and Cases, 2025 • March 14, 2025
This case highlights the challenges in managing DVT in post-surgical patients, specifically in patients with tetraplegia and bleeding risks. The management of patients with concurrent IBD and acute tra...
KEY FINDING: A 53-year-old male with UC and traumatic tetraplegia developed a below the knee DVT during inpatient rehabilitation, despite DVT prophylaxis.
Molecular Medicine Reports, 2020 • January 1, 2020
This study investigated the effects of sacral nerve electrical stimulation (SNS) on defecation function and serotonin (5-HT) levels in a rat model of acute severe spinal cord injury (SCI). The results...
KEY FINDING: SNS significantly increased the quantity of feces, shortened the time to the first fecal passage, and improved fecal texture and colon histology in SCI rats.
Journal of Clinical Medicine, 2021 • March 8, 2021
This pilot study investigated the efficacy and safety of adding transdermal neostigmine and glycopyrrolate, delivered via iontophoresis, to the standard bowel care (SOC) regimen for individuals with s...
KEY FINDING: The addition of transdermal neostigmine and glycopyrrolate significantly reduced the time to bowel evacuation compared to standard of care alone.
Neurotrauma Reports, 2020 • January 1, 2020
This study demonstrates that functional motor and enteric neuroplastic changes affect preferentially the proximal colon compared with the distal colon. Using a rat model of chronic thoracic SCI, we de...
KEY FINDING: The contractile response to bethanechol was significantly decreased in the proximal colon of SCI rats but not in the distal colon.
Turk J Gastroenterol, 2023 • March 14, 2023
This review provides a comprehensive overview of dyssynergic defecation (DD), a common functional disorder of the gastrointestinal tract. The study focuses on diagnostic approaches for DD and briefly ...
KEY FINDING: DD is a common cause of pelvic evacuation disorder, affecting approximately one-third of chronically constipated patients.
Mediators of Inflammation, 2023 • February 8, 2023
This evidence mapping summarizes associations of gut microbiota with neurological or psychiatric disorders, identifying common or differential gut microbiota present in different disorders, which may ...
KEY FINDING: Many studies have investigated the link between gut microbiome alpha diversity and disease, with the Shannon and Simpson indices being the most studied.