Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 101-110 of 1,651 results
Journal of Neuroinflammation, 2021 • September 2, 2021
This study investigates the role of Heat shock transcription factor 1 (HSF1) in suppressing the conversion of A1 astrocytes following spinal cord injury (SCI) in rats. The results showed that HSF1 pro...
KEY FINDING: HSF1 protein levels increase in astrocytes after spinal cord injury in rats, showing colocalization with astrocytes at lesion sites.
Scientific Reports, 2021 • September 22, 2021
This study aimed to characterize the evolution of the cutaneous microbiota of pressure ulcers (PU) in a spinal cord injury (SCI) cohort, analyzing tissue biopsies at baseline and 28 days using 16S rRN...
KEY FINDING: Wounds with a 'Stagnated/Worsened' evolution had a significantly higher relative abundance of Anaerococcus and Finegoldia at baseline (D0).
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2021 • July 8, 2021
This study aimed to investigate the neuroprotective and autophagic effects of IGF‑1 on SCI, and to determine the role of the PI3K/Akt/mTOR signaling pathway in this process. The results of the present...
KEY FINDING: IGF-1 significantly increased cell survival in vitro compared to the control group, suggesting a protective effect on nerve cells.
Curr Biol, 2021 • November 22, 2021
This study investigates the genetic mechanisms underlying the evolutionary transition from preaxial to postaxial limb polarity, focusing on the role of Gli3R activity. Experiments in mice and axolotls...
KEY FINDING: Deletion of 5’Hoxd genes in mice leads to preaxial dominant limb formation, an ancestral trait.
J Cell Mol Med, 2021 • September 19, 2021
This study investigates the inhibitory effect of EV-miRNA-22 on the inflammatory response in spinal cord injury (SCI) in rats. The researchers loaded mesenchymal stem cells (MSCs)-EV with miRNA-22...
KEY FINDING: EV-miRNA-22 could inhibit the occurrence of pyroptosis in microglia, suppress the cell membrane pore opening, and inhibit the release of inflammatory factors and the expression of GSDMD.
PLOS ONE, 2021 • October 14, 2021
This study investigated gene expression changes in the vastus lateralis muscle following different strength training regimes (CON/ECC+ and CON/ECC) during rehabilitation after ACL-R. The results indic...
KEY FINDING: Significant changes were detected in the expression of 26 mRNAs, several of them involved in muscle wasting/atrophy, indicating ongoing muscle remodeling processes.
Frontiers in Cell and Developmental Biology, 2021 • October 15, 2021
The review highlights the complexity of the genetic system involved in central axon regeneration after SCI. Some genes active during development, such as KLF7, SOX11 and STAT3, are potential therapeut...
KEY FINDING: Corticospinal motor neurons (CSMNs) exhibit limited regeneration ability after spinal cord injury compared to other pathways in the central nervous system.
Neurotrauma Reports, 2021 • January 1, 2021
This study investigated the role of microRNAs (miRNAs) in neuropathic pain following spinal cord injury (SCI) by screening miRNA expression in plasma samples from individuals with and without SCI. The...
KEY FINDING: 383 miRNAs were differentially expressed in acute or chronic SCI versus no SCI.
AGING, 2021 • November 12, 2021
This study investigates the role of RIP3-induced JNK signaling in chronic constriction injury (CCI)-induced neuropathic pain. The findings demonstrate that RIP3 inhibition alleviates neuropathic pain ...
KEY FINDING: RIP3 inhibitors (GSK’872) and JNK inhibitors (SP600125) alleviated pain and reduced inflammatory factor levels in CCI rats.
Microbial Biotechnology, 2022 • May 1, 2022
This study investigated the effects of electroacupuncture (EA) on gut microbial dysbiosis and the 5-HT system in spinal cord injury (SCI) rats. EA and fecal microbiota transplantation (FMT) improved i...
KEY FINDING: EA and FMT treatment facilitated intestinal transmission functional recovery and restored the colon morphology of SCI rats.