Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 111-120 of 1,651 results
Redox Biology, 2022 • January 1, 2022
This study investigates the role of Dynamin-related protein 1 (Drp1), a key regulator of mitochondrial fission, in neuropathic pain (NP) using a spared nerve injury (SNI) model in mice. The research f...
KEY FINDING: SNI in mice induces pain behavior and anxiety-like behavior, which is associated with elevation of Drp1, as well as increased density of mitochondria in SDH.
Journal of Cachexia, Sarcopenia and Muscle, 2022 • January 9, 2022
This study demonstrates that Numb protein levels decline with age in skeletal muscle. The loss of Numb in skeletal muscle fibers leads to reduced contractile function, altered sarcomere length, and de...
KEY FINDING: Numb protein expression decreases significantly with age in mouse skeletal muscle.
Frontiers in Bioengineering and Biotechnology, 2022 • January 4, 2022
This study investigates the potential of GDF11, delivered via a lentiviral vector, to promote nerve regeneration after sciatic nerve injury in rats. The findings demonstrate that GDF11 promotes axonal...
KEY FINDING: GDF11 promotes the axonal growth of DRG cells in vitro, suggesting a direct effect on nerve regeneration.
Neural Regeneration Research, 2022 • September 1, 2022
CSPGs inhibit axon regeneration after SCI by interacting with receptors like PTPσ, LAR, and NgRs, activating RhoA and inactivating Akt signaling pathways. ChABC treatment can remove CSPGs, reactivate ...
KEY FINDING: Digestion of CSPGs with ChABC reduces retrograde apoptotic signaling and enhances true axon regeneration in lampreys after spinal cord transection.
Journals of Gerontology: Biological Sciences, 2022 • October 1, 2022
This study characterized the effects of laparotomy on postoperative physical function and skeletal muscle gene expression in male C57BL/6N mice across life span. The study found that laparotomy-induce...
KEY FINDING: Laparotomy induced an age-associated postoperative decline in forelimb grip strength, with the greatest decline in the oldest mice.
BMC Research Notes, 2022 • February 9, 2022
This study investigates the impact of gut microbiota modulation on functional recovery after traumatic peripheral nerve injury (TPNI) in mice. Using antibiotic (ABX)-induced dysbiosis and probiotic (P...
KEY FINDING: Antibiotic (ABX) treatment before a peripheral nerve injury significantly impaired functional recovery in mice.
Frontiers in Physiology, 2022 • February 10, 2022
This study investigated the relationship between visceral adiposity, inflammation, testosterone, and mitochondrial health in individuals with chronic spinal cord injury (SCI). The study found that incr...
KEY FINDING: Citrate synthase (CS) activity, a measure of mitochondrial mass, was negatively associated with visceral adipose tissue (VAT) and C-reactive protein (CRP), an inflammatory marker.
PLoS ONE, 2022 • March 11, 2022
This study investigated the use of peripheral blood mononuclear cells (PBMCs) and near-infrared spectroscopy (NIRS) as less invasive alternatives to muscle biopsies for assessing mitochondrial respira...
KEY FINDING: A significant positive relationship was observed between PBMC and permeabilized skeletal muscle for mitochondrial complex IV (r = 0.86, P < 0.0001), indicating that PBMC measurements can reflect muscle mitochondrial function for this specific complex.
Bone Research, 2022 • April 26, 2022
This review summarizes the latest research progress on two aspects of SCI pathology: intraneuronal microenvironment imbalance and regenerative microenvironment imbalance. We also review repair strateg...
KEY FINDING: The development of a combined, precise, and multitemporal strategy for repairing the injured spinal cord is a potential future direction.
Cell Death Discovery, 2022 • April 28, 2022
This study investigates the effects of thrombin, a serine protease, on astrocytes following spinal cord injury (SCI) in rats. SCI leads to increased thrombin levels, which activate protease-activated ...
KEY FINDING: Thrombin reverses astrocytic stellation, promoting proliferation but inhibiting migration.