Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 91-100 of 1,651 results
Glia, 2021 • September 1, 2021
This study demonstrates that genetic knockout of PAR1 in mice improves sensorimotor outcomes and neural repair after spinal cord injury. The improved outcomes are associated with reduced inflammation,...
KEY FINDING: Genetic blockade of PAR1 in female mice results in improvements in sensorimotor co-ordination after thoracic spinal cord lateral compression injury.
Dev Dyn, 2022 • June 1, 2022
This paper addresses the critical need for standardized gene and transgenic nomenclature in axolotl research. Recent advancements in genetic and molecular tools have greatly accelerated work with axol...
KEY FINDING: The paper proposes a set of guidelines for gene and transgenic nomenclature in the axolotl, covering species symbols, gene/mRNA/cDNA, protein naming, paralogs/orthologs, novel genes, transcript variants, non-coding transcripts, and mitochondrial genes.
Redox Biology, 2021 • April 22, 2021
This study investigates the mechanism of motor neuron death following spinal cord injury (SCI), focusing on the role of iron overload and ferroptosis in the motor cortex. The study demonstrates that S...
KEY FINDING: SCI induces iron overload in the motor cortex of both human patients and rat models.
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2021 • February 2, 2021
This study demonstrated that inhibiting STAT3 not only promoted NSC differentiation into neurons, but also inhibited their differentiation into astrocytes, potentially through mTOR activation. The tra...
KEY FINDING: Knocking down STAT3 expression in rat NSCs promoted their neuronal differentiation in vitro, and upregulated the activity of mTOR.
Biomed Pharmacother, 2021 • August 1, 2021
The review highlights the role of non-coding RNAs (ncRNAs), including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), in stroke pathophysiology and recovery. Exosomes, as nanocarriers, transpor...
KEY FINDING: LncRNAs like MALAT1, ANRIL, and H19 affect angiogenesis, inflammation, autophagy and apoptosis following ischemic stroke.
Journal of Neuroinflammation, 2021 • January 1, 2021
This study identifies D-DT as a novel inflammatory activator of astrocytes following spinal cord injury, suggesting it could be a beneficial target for anti-inflammation drug development in neuropatho...
KEY FINDING: D-DT expression is induced in astrocytes and neurons, but not microglia, following spinal cord contusion, indicating a cell-specific response to injury.
Cell Death Discovery, 2021 • May 14, 2021
This study investigates the role of CtBP and Snail in tumor invasion using Drosophila as a model organism. The researchers found that both CtBP and Snail are required for tumor growth and invasion tri...
KEY FINDING: Depletion of CtBP or Snail (Sna) suppressed RasV12/lgl-/--triggered tumor growth and invasion, and disrupted cell polarity-induced invasive cell migration in Drosophila.
Current Neuropharmacology, 2022 • January 1, 2022
This review summarizes current knowledge about four epigenetic modifications—DNA/RNA methylation, histone acetylation, and circRNAs—in chronic pain. Epigenetic modifications may shed lights on the chr...
KEY FINDING: DNA methylation, mediated by enzymes like DNMTs and TETs, plays a role in chronic pain development. Specifically, the upregulation of methyltransferase DNMT3a is widely involved in chronic pain induced by a variety of causes, and it promotes the occurrence and development of chronic pain by inhibiting the transcription of analgesic-related genes by increasing the methylation level of these genes.
The Journal of Neuroscience, 2021 • October 13, 2021
This study investigates the role of astrocyte CD38 in myelin injury and regeneration, focusing on the impact of high-fat diets on oligodendrocytes and myelin integrity. The findings demonstrate that h...
KEY FINDING: High-fat diet consumption increases CD38 expression in astrocytes, leading to NAD1 depletion in the spinal cord.
BIOENGINEERED, 2021 • August 4, 2021
This study investigates the role of circSMEK1 in neuropathic pain (NP) using rat and cell models. The results indicate that circSMEK1 and TXNIP are upregulated in NP, while miR-216a-5p is downregulate...
KEY FINDING: CircSMEK1 and TXNIP are upregulated in neuropathic pain (NP), while miR-216a-5p is downregulated.