Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 151-160 of 1,651 results
Pain Research and Management, 2020 • April 10, 2020
This study investigates the effect of 2 Hz electroacupuncture (EA) on neuropathic pain in rats with spared nerve injury (SNI), focusing on the role of interferon regulatory factor 8 (IRF8) and CX3CRl ...
KEY FINDING: Spared nerve injury (SNI) significantly increased spinal IRF8 and CX3CRl mRNA and protein expression in rats.
International Journal of Molecular Sciences, 2020 • April 30, 2020
This systematic review examines the potential benefits of Actovegin® in treating ischemic stroke, focusing on its pleiotropic actions on injury pathways. The review highlights Actovegin®'s actions in ...
KEY FINDING: Actovegin® improves tissue oxygen and glucose consumption and energy production, especially in the hippocampus, an area linked to learning and memory.
Scientific Reports, 2020 • May 22, 2020
In five patients with acute, severe thoracic traumatic spinal cord injuries (TSCIs), American spinal injuries association Impairment Scale (AIS) grades A–C, we induced cord hypothermia (33 °C) then re...
KEY FINDING: Cooling did not affect cord physiology (ISP, SCPP), but markedly altered cord metabolism and markedly reduced cord inflammation.
Cells, 2020 • May 25, 2020
This study aimed to examine changes in neuronal DNA methylation status after SCI and to determine whether modulation of DNA methylation with ascorbic acid can enhance neuronal regeneration or function...
KEY FINDING: SCI induces alteration of 5mC and 5hmC Levels in the Brain Motor Cortex. The intensity of 5hmC was significantly higher in the SCI group than in the control group at 1 day (acute stage) and 1 week after injury.
Molecular Medicine Reports, 2020 • April 22, 2020
The study investigated the effects of electroacupuncture (EA) on microRNA (miRNA) expression profiles in spinal cord injury (SCI) rats to understand the potential mechanisms involved in SCI recovery. ...
KEY FINDING: Electroacupuncture (EA) treatment improved hindlimb motor function in spinal cord injury (SCI) rats, as indicated by higher Basso, Beattie and Bresnahan (BBB) scores.
AGING, 2020 • June 9, 2020
This study investigates the role of Mlxipl in neuropathic pain (NP), focusing on its impact on neuroinflammation in the spinal dorsal horn (SDH) following peripheral nerve injury. The key findings dem...
KEY FINDING: Mlxipl expression is upregulated in the ipsilateral spinal dorsal horn (SDH) of rats with Spared Nerve Injury (SNI)-induced mechanical allodynia.
Cell Death & Disease, 2020 • July 23, 2020
This article is a correction to a previously published paper in Cell Death & Disease. The original publication had an error where Figure 6 was displayed incorrectly. The correction replaces the incorr...
KEY FINDING: The original article had an error in Figure 6.
Oxidative Medicine and Cellular Longevity, 2020 • August 28, 2020
Ferroptosis is a nonapoptotic cell death mechanism marked by iron dependence and lipid peroxidation, contributing to various diseases, including nervous system disorders and spinal cord injury. The me...
KEY FINDING: Ferroptosis is linked to spinal cord injury (SCI) in animal models. Inhibiting ferroptosis shows promise in promoting neurological function recovery after SCI.
J Cell Mol Med, 2020 • August 17, 2020
This study investigates the effects of mechanical stress and decompression on autophagy and apoptosis after spinal cord injury (SCI) in a rabbit model. The results indicate that decompression reduces ...
KEY FINDING: Decompression reduces intramedullary pressure (IMP) after spinal cord injury (SCI), with piotomy showing the most significant decrease.
Brain Sciences, 2020 • November 6, 2020
This study examined the effects of epidural stimulation (ES) and locomotor training on plasticity-related molecules and synaptic changes in spinal motoneurons following complete spinal transection in ...
KEY FINDING: The total amount of CSPG expression significantly increased with time after spinal cord injury, but locomotor training did not affect CSPG expression.