Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 201-210 of 1,651 results
Frontiers in Molecular Neuroscience, 2023 • February 2, 2023
This review discusses the role of microRNAs (miRNAs) in spinal cord injury (SCI), emphasizing their involvement in secondary injury mechanisms like neuroinflammation, apoptosis, and oxidative stress. ...
KEY FINDING: miRNAs regulate the expression of proteins altered after SCI by up-regulating or down-regulating target genes, influencing processes like inflammatory response, angiogenesis, and axon regeneration.
J Cell Mol Med, 2020 • January 1, 2020
This study investigates the effects of low-level laser therapy (LLLT) on macrophage polarization and neurotrophic factor secretion in an in vitro model of spinal cord injury (SCI). The results demonst...
KEY FINDING: LLLT irradiation decreased the expression of M1 macrophage-specific markers and increased the expression of M2 macrophage-specific markers in vitro.
Frontiers in Cellular Neuroscience, 2021 • February 18, 2021
This study examined the impact of ApoE variants on functional recovery after spinal cord injury (SCI) in transgenic mice expressing either human ApoE3 or ApoE4. The findings indicate that ApoE4 mice e...
KEY FINDING: ApoE4 mice showed worse locomotor function and coordination after SCI compared to ApoE3 mice, as measured by the Basso Mouse Scale (BMS) and ladder rung walk test (LRWT).
Neurosci. Bull., 2020 • September 5, 2020
The study examined the effects of conventional spinal cord stimulation (SCS) on microglial activation in rats with chronic constriction injury (CCI) of the sciatic nerve, a model of neuropathic pain. ...
KEY FINDING: Conventional SCS transiently attenuated mechanical hypersensitivity in rats with chronic constriction injury (CCI) of the sciatic nerve.
Neural Plasticity, 2021 • April 19, 2021
The study investigates the role of the Wnt/β-catenin pathway in neuropathic pain (NP) induced by chronic compression of the dorsal root ganglion (DRG). The researchers used a rat model to mimic lumbar...
KEY FINDING: Chronic compression of the DRG leads to changes in the expression of multiple Wnt pathway-related genes and rapid activation of the Wnt/β-catenin pathway in the DRG and spinal cord.
Nutrients, 2020 • January 3, 2020
The study investigates the antinociceptive and anti-inflammatory effects of Nypa fruticans Wurmb extracts (NFE) in a rat model of sciatic nerve crush injury, focusing on the role of TRPV1. Results ind...
KEY FINDING: NFE (500 mg/kg) significantly delayed paw withdraw reaction in thermal hyperalgesia test compared to the vehicle group.
Oxidative Medicine and Cellular Longevity, 2021 • February 27, 2021
Spinal cord injury (SCI) results in an imbalance between reactive oxygen species (ROS) production and antioxidant defenses, leading to oxidative stress. Dietary advice and supplements, particularly th...
KEY FINDING: Curcumin, ginseng, and green tea have potential for SCI management, but SCI individuals often have low antioxidant vitamin levels.
Nature Communications, 2019 • September 13, 2019
This study identifies circAnks1a as a key regulator in neuropathic pain, showing its expression is increased following nerve injury in a rodent model. Reducing circAnks1a levels alleviates pain-like b...
KEY FINDING: Spinal nerve ligation increases circAnks1a expression in dorsal horn neurons.
Int. J. Mol. Sci., 2022 • December 14, 2022
The study validates that burn injury results in sciatic nerve demyelination and that Schwann cell dedifferentiation increases the expression of the immature marker p75 and reduces that of the maturate...
KEY FINDING: Spinal irisin gene delivery attenuates burn injury-induced sciatic nerve demyelination and reduction of neuromuscular junction innervation.
J Cell Mol Med, 2020 • January 1, 2020
This study aimed to investigate the role of miR-30b in promoting sensory function recovery after spinal cord injury (SCI) by enhancing primary sensory neuron (PSN) axon growth. The results demonstrate...
KEY FINDING: MiR-30b promotes primary sensory neuron axon growth in vitro by targeting and degrading sema3A mRNA.