Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 221-230 of 1,651 results
Cell Mol Neurobiol, 2017 • May 28, 2016
This study investigates the expression and role of Sam68, an RNA-binding protein, in spinal cord injury (SCI). The researchers found that Sam68 protein levels increase significantly after SCI in rats....
KEY FINDING: Sam68 protein levels are significantly increased in a rat model of spinal cord injury (SCI), peaking at day 3 and returning to normal by day 14.
International Journal of Molecular Sciences, 2014 • October 20, 2014
This study demonstrates that exercise preconditioning (EP) upregulates neuronal and astroglial heat shock protein 72 (HSP 72) in the spinal cord of rats, providing protection against spinal cord injur...
KEY FINDING: Exercised rats with spinal cord injury (SCI) had significantly higher levels of neuronal and astroglial HSP 72 compared to non-exercised rats with SCI.
Cell and Tissue Research, 2022 • November 25, 2021
Rodent studies tracing endogenous NSCs in injuries and disease have revealed diversified roles for these cells depending on the model system. In SCI-based models, many endogenous NSCs have been found ...
KEY FINDING: Endogenous NSCs can contribute to reactive gliosis by differentiating into reactive astrocytes, while in other models, they can provide new myelination and neural replacement.
PLoS ONE, 2017 • July 10, 2017
This study investigates regional differences in astrocyte expression of GFAP and ALDH1L1 across the brain and spinal cord during development and in response to demyelination. The results demonstrate t...
KEY FINDING: GFAP expression is higher in the developing and adult spinal cord compared to the brain.
PLoS ONE, 2016 • August 3, 2016
The study investigated the distinct effects of active muscle contraction, passive vibration, and whole-body heat stress on skeletal muscle gene regulation in humans. The purpose was to examine whether...
KEY FINDING: Repetitive active muscle contractions upregulated metabolic transcription factors and repressed MSTN.
The Journal of Neuroscience, 2016 • August 10, 2016
The study investigates the role of miR-155 in spinal cord injury repair, focusing on its impact on both neuron-intrinsic and neuron-extrinsic mechanisms. The research demonstrates that miR-155 deletio...
KEY FINDING: Deleting miR-155 attenuates inflammatory signaling in macrophages, reduces macrophage-mediated neuron toxicity, and increases macrophage-elicited axon growth.
Neurobiol Dis., 2015 • February 1, 2015
The study investigated the role of neutrophil elastase (NE) in acute and chronic outcomes after traumatic brain injury (TBI) in the developing brain of mice. Results showed that NE contributes to acut...
KEY FINDING: Genetic deletion or inhibition of NE results in alleviation of acute cell death, strongly implicating NE in early post-injury pathogenesis.
PLoS ONE, 2014 • December 22, 2014
This study investigated the impact of minimal-dose electrical stimulation on gene regulation in paralyzed human muscle after spinal cord injury (SCI). The key finding was that acute electrical stimula...
KEY FINDING: Acute stimulation of paralyzed muscle regulates over 100 biological pathways as compared to less than 30 in chronically trained muscle.
Exp Neurol, 2015 • March 1, 2015
This study investigates the association of microRNAs (miRNAs) with hippocampal mitochondria and changes in their expression following controlled cortical impact (CCI) injury in rats. The findings demo...
KEY FINDING: The miRNA processing proteins Argonaute (AGO) and Dicer are present in mitochondria fractions from uninjured rat hippocampus, suggesting functional RNA-induced silencing complexes are present.
Ann Rehabil Med, 2016 • August 1, 2016
This study demonstrates that following spinal cord injury (SCI), astrocyte proliferation occurs in the hippocampus, and motor neuron cell death occurs in the motor cortex. The study also found signifi...
KEY FINDING: BDNF expression was significantly elevated at 2 weeks after injury.