Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 311-320 of 1,651 results
FEBS Open Bio, 2019 • May 2, 2019
This study investigates the role of TCTN2 long non-coding RNA on apoptosis and autophagy in SCI. The data suggest that TCTN2 enhances autophagy by targeting the miR-216b–Beclin-1 pathway, thereby amel...
KEY FINDING: TCTN2 expression is decreased in spinal cord tissues of rats with SCI and in oxygen–glucose deprivation (OGD)-induced hypoxic SY-SH-5Y cells, while miR-216b is up-regulated in these conditions.
Pain Research and Management, 2019 • April 28, 2019
The study aimed to clarify the mechanisms underlying pain reduction by PRF treatment on DRG, focusing on the levels of BDNF, PI3K, and p-ERK in the spinal cord of rats with spared nerve injury (SNI). ...
KEY FINDING: SNI induced a long-lasting increase in microglia hyperactivity and BDNF, PI3K, and p-ERK upregulation in the spinal cord and resulted in pain sensitization.
Physiol Rep, 2019 • July 1, 2019
This study investigated the interactive effects of myostatin (Mstn) and AdipoRon on hepatic gene expression and function in a mouse hepatocyte line. Mstn increased fatty acid accumulation and desensit...
KEY FINDING: Myostatin (Mstn) increases fatty acid accumulation and desensitizes cellular responses to insulin in hepatocytes.
Annals of Rehabilitation Medicine, 2019 • July 1, 2019
This study investigated the potential of miRNA-21 and miRNA-223 as indicators of the severity and acute phase of spinal cord injury (SCI) using a balloon-compression model in rats. The results showed ...
KEY FINDING: Significant differences in miRNA-21 expression levels were observed between the experimental groups at 1, 3, and 7 days post-injury, suggesting that miRNA-21 expression levels might serve as an indicator of the severity of SCI.
Physiol Rep, 2019 • August 5, 2019
This study examined the effects of spinal cord injury (SCI) on oxidative stress and antioxidant defenses in human skeletal muscle over the first year post-injury. Muscle biopsies were analyzed at 1, 3...
KEY FINDING: Increased protein content of NADPH oxidase 2, xanthine oxidase, and pro-caspase-3 was observed at 1 and 3 months after spinal cord injury compared to able-bodied controls, suggesting increased ROS production and apoptotic signaling.
Am J Transl Res, 2019 • August 30, 2019
This study evaluated neurogenic bowel management and gut microbiota changes in patients with TCSCI, exploring associations with serum biomarkers. Results indicated moderate NBD in TCSCI patients, lowe...
KEY FINDING: Patients with TCSCI had lower gut microbiota diversity and altered structural composition compared to healthy males.
Cellular & Molecular Biology Letters, 2024 • November 20, 2024
This study investigates the role of ASIC1A in spinal cord injury (SCI). It reveals that ASIC1A activation in neural stem cells (NSCs) prevents their differentiation into oligodendrocytes, hindering my...
KEY FINDING: ASIC1A is upregulated in NSCs following spinal cord injury.
Molecular Therapy: Methods & Clinical Development, 2021 • December 1, 2021
This study reports the unexpected finding that AAV vectors accumulate in the pineal gland following injections into the brain, spinal cord, or cerebrospinal fluid (CSF). Different AAV serotypes, inclu...
KEY FINDING: AAV vectors accumulate in the pineal gland following injections into the brain, spinal cord, or cerebrospinal fluid.
Frontiers in Physiology, 2012 • October 10, 2012
The present review discusses the features of spinal cord plasticity with a specific emphasis on protecting against maladaptive plasticity in nociceptive systems and promoting adaptive forms of spinal p...
KEY FINDING: Spinal synapses can be strengthened or weakened in response to external stimulation, demonstrating the basic properties required for use-dependent learning and memory.
PLoS ONE, 2012 • November 8, 2012
This study explored the impact of the ACTN3 R577X polymorphism on single muscle fiber contractile properties in individuals with spinal cord injury (SCI). The SCI condition provided a standardized env...
KEY FINDING: Absence of a-actinin-3 (XX genotype) resulted in a limitation in the shift of muscle composition towards type IIx fibers and preservation of type I fibers in response to long-term muscle disuse.