Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 61-70 of 1,651 results
Frontiers in Cellular Neuroscience, 2024 • May 22, 2024
This study compared the effects of BMP4 alone and a bFGF/BMP4 combination on neural stem cells (NSCs) in vitro, using RNA sequencing to analyze transcriptome profiles and immunofluorescence to validat...
KEY FINDING: Both BMP4 alone and bFGF/BMP4 combination induce a quiescent state in neural stem cells (qNSCs), but they result in different levels of quiescence.
AGING, 2024 • June 5, 2024
This study investigates the potential of Daphnoretin, a natural compound, to treat spinal cord injury (SCI) by reducing inflammation and promoting motor function recovery in mice. The findings demonst...
KEY FINDING: Daphnoretin attenuated the loss of movement ability in mice after SCI, suggesting it has a protective effect on motor function.
Neurospine, 2024 • June 1, 2024
This study demonstrates that MSC-Exo treatment can effectively inhibit ferroptosis in BV2 cells and promote neurological recovery in SCI rats. The Nrf2/GCH1/BH4 signaling pathway plays a crucial role ...
KEY FINDING: MSC-Exo effectively inhibited the production of ferrous iron, lipid peroxidation products, and ferroptosis-promoting factor prostaglandin-endoperoxide synthase 2.
Journal of Orthopaedic Surgery and Research, 2024 • June 25, 2024
This study investigates the therapeutic effects of repetitive transcranial magnetic stimulation (rTMS) on spinal cord injury (SCI) in mice and the related mechanisms, focusing on the role of astrocyte...
KEY FINDING: High-frequency repetitive transcranial magnetic stimulation (HF-rTMS) significantly reduces Cx43 expression on astrocytes.
Int. J. Mol. Sci., 2024 • June 29, 2024
The study investigated the effects of intramuscular pulsed radiofrequency (PRF) on complicated pain using a two-stage animal study. The first stage examined the effects of PRF on muscle and sciatic ne...
KEY FINDING: PRF upregulates brain-derived neurotrophic factor (BDNF) in the spinal cord in both groups of rats.
Int. J. Mol. Sci., 2024 • July 21, 2024
This study aimed to evaluate the effect of adding aquatic therapy to standard physiotherapy treatment on systemic inflammation in SCI patients, also assessing the relationship between cytokine blood l...
KEY FINDING: The study identified a complex signature of five cytokines (IL-12p70, IL-8, MCP-1, IL-1α, and IP10) associated with the time course of the two physiotherapy programs.
Spinal Cord Series and Cases, 2024 • July 15, 2024
This retrospective study evaluated the frequency of calcium homeostasis marker assessment in patients with acute traumatic spinal cord injury (TSCI) at a level 1 trauma center. The study revealed that...
KEY FINDING: Most calcium homeostasis markers, besides calcium itself, were not routinely checked in patients admitted after traumatic spinal cord injury.
Biological Research, 2024 • August 5, 2024
The in situ overexpression of NeuroD1 and Ngn2 in the spinal cord after spinal cord injury can reprogram astrocytes into neurons and significantly enhance cell regeneration at the injury site. The rep...
KEY FINDING: Overexpression of NeuroD1 and Ngn2 in astrocytes promotes cell regeneration at the injury site after spinal cord injury.
Scientific Reports, 2024 • September 12, 2024
This study investigates the role of HMGB1 in promoting CCL5 production by astrocytes after spinal cord injury (SCI). The results demonstrate that HMGB1, via TLR2/4 receptors and the MAPK/NF-κB pathway...
KEY FINDING: SCI increases CCL5 and HMGB1 protein levels synchronously at the lesion site.
Int. J. Mol. Sci., 2024 • September 23, 2024
The study investigated the acute molecular responses after a 3 Hz or 1 Hz electrically induced exercise program in people with complete spinal cord injury, with a constant number of pulses delivered i...
KEY FINDING: The 3 Hz electrically induced exercise resulted in the upregulation of early response genes (NR4A3, PGC-1α, ABRA, IRS2, EGR1, ANKRD1, and MYC).