Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 71-80 of 1,651 results
Int. J. Mol. Sci., 2024 • October 1, 2024
This study investigates the role of miR-19a and miR-19b in microglia activation and neuroinflammation using transcriptomic profiling of primary microglia. The results demonstrate that miR-19a and miR-...
KEY FINDING: miR-19a and miR-19b up- and downregulate different genes, leading to distinct inflammatory responses in microglia.
Journal of Inflammation Research, 2024 • November 6, 2024
This cross-sectional study explored the relationship between the systemic immune-inflammation index (SII) and deep venous thrombosis (DVT) in patients with spinal cord injury (SCI). The study found a ...
KEY FINDING: A positive association between SII and the risk for DVT was observed (odds ratio 1.39 [95% CI 1.03–1.87]; P=0.032), independent of confounders.
Molecular Medicine, 2024 • November 7, 2024
This study investigates the causal relationship between mitochondrial abnormalities and chronic post-sepsis muscle weakness, exploring potential therapeutic targets. The findings demonstrate that post...
KEY FINDING: Post-sepsis skeletal muscle weakness develops progressively after the resolution of acute sepsis and is linked to mitochondrial abnormalities.
European Journal of Applied Physiology, 2025 • November 22, 2024
This study aimed to determine whether evoking knee extensor (KE) muscle hypertrophy prior to FES-LEC training would further augment mitochondrial enzymatic activity than simply using FES-LEC only. The...
KEY FINDING: Both interventions demonstrated a time effect on CS (P = 0.001) with interaction between both groups (P = 0.01).
Cells, 2024 • November 6, 2024
Microglia-derived exosomes (MGEVs) play a dual role in the central nervous system (CNS), contributing to both neuroprotection and neurodegeneration depending on their cargo and the state of the parent...
KEY FINDING: MGEVs from anti-inflammatory microglia can support neurorepair and cell survival by delivering neurotrophic factors and anti-inflammatory mediators.
Scientific Reports, 2024 • December 2, 2024
This study investigates the role of bone marrow mesenchymal stem cells (BMMSCs) and miR-202-3p in treating spinal cord injury (SCI) in rats. The research demonstrates that BMMSCs, mediated by miR-202-...
KEY FINDING: BMMSCs improve motor function recovery in SCI rats, as evidenced by increased BBB scores and improved footprint analysis.
European Journal of Medical Research, 2024 • January 1, 2024
The study investigated the mechanism by which pulsed radiofrequency (PRF) alleviates neuropathic pain (NP) in a rat model of chronic constriction injury (CCI). PRF treatment was found to alleviate NP ...
KEY FINDING: PRF treatment alleviated NP in CCI rats, and upregulated the expression of MG53 while inhibiting microglial activation.
CANCER BIOLOGY & THERAPY, 2024 • December 3, 2024
This study investigates the efficacy of dinaciclib, a Cdk inhibitor, in treating biliary tract cancer (BTC) using in vitro models. The findings indicate that dinaciclib reduces cell viability, ATP lev...
KEY FINDING: Dinaciclib reduces cell viability, ATP levels, and proliferation rates in BTC cells.
Journal of Cellular and Molecular Medicine, 2025 • January 1, 2025
This study investigates the potential therapeutic role of resveratrol (RES) and miR-124-3p in mitigating pyroptosis and promoting recovery from spinal cord injury (SCI). The research demonstrates that...
KEY FINDING: DAPK1 interacts with NLRP3, promoting pyroptosis via the NLRP3/Caspase-1/GSDMD pathway. Knocking down DAPK1 inhibits pyroptosis.
Cell & Bioscience, 2025 • January 23, 2025
This study demonstrates that trehalose enhances myelin debris clearance and reduces foamy macrophage formation after SCI by inducing TFEB expression in macrophages and modulating the autophagy-lysosom...
KEY FINDING: Trehalose enhances macrophage phagocytosis and clearance of myelin debris in a dose-dependent manner in vitro, with an optimal concentration of 20 mM.