Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 1-10 of 620 results
BMC Pulmonary Medicine, 2024 • October 7, 2024
This study investigated the relationship between plasma fibrinogen levels and the incidence of pulmonary infection (PI) in patients with spinal cord injury (SCI). The study found that elevated plasma ...
KEY FINDING: For every 1 g/L increase in fibrinogen level, the risk of developing PI increased by 18% (HR = 1.18, P = 0.011), and indicating a positive linear relationship between fibrinogen level and PI incidence.
The Journal of Spinal Cord Medicine, 2023 • January 1, 2021
This review examines spinal cord disorders associated with SARS-CoV-2, finding a variety of manifestations like acute transverse myelitis and acute necrotizing myelitis. The mechanisms of spinal cord ...
KEY FINDING: COVID-19-related spinal cord manifestations include acute transverse myelitis, acute necrotizing myelitis, SARS-CoV-2 myelitis, acute disseminated encephalomyelitis and others.
The Journal of Spinal Cord Medicine, 2023 • January 1, 2023
This retrospective cohort study elucidated the incidence and risk factors for pneumonia after acute traumatic cervical spinal cord injury (CSCI). The study revealed that aspiration pneumonia is common...
KEY FINDING: The incidence of pneumonia following traumatic cervical spinal cord injury was 18%, with 87% of these cases being aspiration-related.
The Journal of Spinal Cord Medicine, 2023 • June 28, 2022
This study investigated the safety and feasibility of intravesical hyaluronic acid with chondroitin sulphate (HA+CS) instillations in preventing urinary tract infections (UTIs) in patients with acute ...
KEY FINDING: HA+CS was well tolerated by participants with spinal cord injury.
Neurol Neuroimmunol Neuroinflamm, 2023 • May 1, 2023
The study provides evidence for de novo post-traumatic antibody synthesis at the spinal cord lesion site and emerging antibody-mediated autoimmunity after human SCI, directed against spinal cord and D...
KEY FINDING: A subpopulation of SCI patients (16%) developed autoantibodies that bind to spinal cord epitopes and DRG neurons, while these were absent in vertebral fracture controls.
Cureus, 2023 • March 17, 2023
This case report presents a rare instance of carpal osteomyelitis in a 62-year-old male with a spinal cord injury (SCI). The patient was successfully treated with antibiotics, avoiding surgical interv...
KEY FINDING: Carpal osteomyelitis is rare in SCI patients and can be challenging to diagnose due to nonspecific symptoms and lab markers.
Biology, 2023 • April 19, 2023
Patients in the SCI-ECP (5 to 15 years post-injury) and SCI-LCP (>15 years post-injury) groups seemed to present an increased proportion of CD4+ CD25+/low Foxp3+ Tregs in comparison to healthy subject...
KEY FINDING: There was a significant increase in the amount of circulating CD4+ CD25+ Foxp3+ in SCI-LCP compared to HC and SCI-ECP.
Int. J. Mol. Sci., 2023 • April 11, 2023
The study demonstrates an altered profile of cytokine-producer T cells in patients with chronic SCI, with notable changes throughout the course of the disease. Significant variations in cytokine produ...
KEY FINDING: Patients with late-chronic SCI (SCI-LCP) exhibit a significant increase in the spontaneous expression of IL-10 by CD4 cells in comparison to healthy controls (HC) and SCI-SP.
Int. J. Mol. Sci., 2023 • May 2, 2023
This review discusses the role of cAMP-specific PDE inhibition in modulating neuroinflammation and promoting neuroregeneration following SCI in rodent models. The review highlights the potential of PD...
KEY FINDING: Inhibition of cAMP-specific PDEs, particularly PDE4, PDE7, and PDE8, shows potential in managing neuroinflammation and promoting regeneration in the central nervous system after SCI.
Journal of Neurotrauma, 2023 • December 1, 2023
This study longitudinally profiled immunological changes in individuals with SCI during the first year post-injury, identifying dynamic molecular and cellular changes using RNA sequencing, flow cytome...
KEY FINDING: Reduced expression of NK cell genes was observed within the first 6 months post-injury, consistent with reduced frequencies of CD56bright and CD56dim NK cells at 12 months post-injury.