Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 611-620 of 620 results
Journal of Inflammation Research, 2021 • January 1, 2021
This study aimed to determine the incidence of occult infections (OI) in patients receiving autologous bone grafting (ABG) for non-union (NU) treatment, evaluate its impact on the outcome, and identif...
KEY FINDING: The incidence of occult infections after non-union treatment of the lower limb remains at 9.04% despite thorough preoperative screening.
PNAS, 2022 • February 24, 2022
The study characterizes the landscape of m5C mRNA modifications in Plasmodium parasites, revealing higher levels in gametocytes. It identifies NSUN2 as a major mRNA m5C methyltransferase. Knockout of ...
KEY FINDING: m5C mRNA methylation is strikingly enhanced in the transcriptomes of gametocytes in both Plasmodium yoelii and Plasmodium falciparum.
Cellular & Molecular Immunology, 2020 • October 27, 2020
This study investigates the effects of the small-molecule TPN10456 on Th17 cell differentiation and its potential therapeutic role in multiple sclerosis (MS). The research demonstrates that TPN10456 ...
KEY FINDING: TPN10456 inhibits Th17 cell differentiation in a dose-dependent manner. The addition of TPN10456 resulted in a dose-dependent reduction in the frequency of IL-17A-producing cells.
Sci Immunol, 2019 • July 5, 2019
This study investigates the migratory behavior of human skin-resident memory T cells (TRM), challenging the concept of strict tissue compartmentalization. The research identifies a circulating populat...
KEY FINDING: Human skin CD4+ TRM can downregulate CD69 and exit the skin.
The Journal of Spinal Cord Medicine, 2016 • May 1, 2016
This study examined the cross-sectional associations between systemic inflammation and oxidative stress with pulmonary function in individuals with chronic spinal cord injury (SCI). The objective was ...
KEY FINDING: Higher levels of systemic inflammation (CRP and IL-6) were associated with lower percent-predicted FEV1 and FVC measurements in individuals with chronic SCI. participants with higher levels of CRP and IL-6 had lower percent-predicted FEV1 and FVC measurements.
FEBS Open Bio, 2022 • January 1, 2022
This study identifies differentially-expressed innate immune-related genes and hub genes following spinal cord injury (SCI). Temporal expression patterns of these genes were analyzed and validated to ...
KEY FINDING: Nine hub genes (Ccl2, Stat3, Mapk14, Stat1, Tlr2, Cxcl10, Myd88, Itgam, and Mapk8) were identified as key players in the innate immune response after SCI.
Cell Mol Neurobiol, 2010 • July 14, 2010
This is a retraction note for an article originally published online on July 14, 2010, in Cellular and Molecular Neurobiology. The reason for the retraction is the duplication of a significant amount ...
KEY FINDING: The original article (DOI 10.1007/s10571-009-9449-4) has been retracted.
Frontiers in Aging Neuroscience, 2022 • December 7, 2022
This review synthesizes recent advances in understanding the immune response following spinal cord injury (SCI), highlighting the dual roles of various immune components in either promoting or hinderi...
KEY FINDING: Glial cells in the spinal cord, like astrocytes and microglia, are not just supportive cells but also key players in the immune response after SCI, influencing inflammation and tissue repair.
Exp Neurol, 2016 • August 1, 2016
This study investigates the remote effects of thoracic spinal cord injury (SCI) on the lumbar region, focusing on myeloid cell infiltration and its impact on locomotor networks. The findings reveal th...
KEY FINDING: Myeloid cell infiltration occurs in the lumbar cord, but not the cervical region, after thoracic SCI.
Journal of Infection, 2020 • March 3, 2020
This letter to the editor discusses a study on the impact of low-dose corticosteroid therapy on viral clearance in COVID-19 patients. The study analyzed data from 78 patients and found no significant ...
KEY FINDING: Low-dose corticosteroid therapy does not significantly delay viral clearance in patients with COVID-19.