Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 161-170 of 620 results
Eur Spine J, 2007 • November 14, 2006
The study presents a rare case of cervical intramedullary brucellar granuloma (IBG) in a 35-year-old female, who had a history of Brucella meningitis and improper medication intake. The patient presen...
KEY FINDING: This case represents the first reported instance of intramedullary granuloma of the cervical spine caused by Brucella. Prior cases involved the thoracic spine or conus medullaris.
Oncotarget, 2017 • April 27, 2017
The study identifies TRIM32 as a novel essential positive factor modulating axonal regeneration and the recovery of motor function following SCI. TRIM32 deficiency results in impaired axonal regenerat...
KEY FINDING: TRIM32 expression is upregulated in astrocytes and microglia following spinal cord injury.
J Spinal Cord Med, 2007 • January 1, 2007
The study aimed to determine if immune responsiveness varies between areas with intact and impaired innervation in stroke patients using delayed hypersensitivity testing. The results indicated no sign...
KEY FINDING: Response to delayed hypersensitivity testing did not differ significantly between affected and unaffected arms in stroke patients.
BMJ Case Rep, 2017 • May 29, 2017
This case report describes a patient with cervical spinal cord injury and quadriparesis who developed prolonged fever. Initial treatment focused on a catheter-related bloodstream infection, but the fe...
KEY FINDING: QUAD fever should be considered in patients with high spinal cord injuries who present with fever and when other causes have been excluded.
Journal of Neuroinflammation, 2008 • June 25, 2008
This study investigates the expression of complement mRNAs and the presence of complement proteins associated with polymorphonuclear leukocytes (PMNs) after spinal cord injury (SCI). Cultured PMNs exp...
KEY FINDING: Stimulated or unstimulated PMNs expressed mRNAs encoding for C1q, C3, and C4, but not C5, C6, C7 or C9 in culture. Complement protein C1q or C3 was also detected in less than 30% of cultured PMNs.
The Journal of Neuroscience, 2008 • December 17, 2008
This study investigates the role of C1q, a component of the classical complement pathway, in spinal cord injury (SCI) using C1q knock-out (KO) mice on a complement-sufficient background (BUB). The key...
KEY FINDING: BUB C1q KO mice exhibited greater locomotor recovery compared with BUB WT mice.
BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES, 2009 • January 1, 2009
This study investigates catheter-related urinary tract infections (UTIs) in patients with spinal cord injuries (SCI), focusing on the etiology, antimicrobial susceptibility, and correlation with bladd...
KEY FINDING: The majority of UTIs and bacteriuria cases were caused by Gram-negative bacilli and enterococci, typical inhabitants of the bowel and perineum and common in hospital environments.
J Spinal Cord Med, 2009 • August 1, 2009
This prospective observational study investigated the nosocomial transmission of highly resistant microorganisms (HRMOs) in a spinal cord rehabilitation ward. The study found a strong correlation betw...
KEY FINDING: Nine different HRMOs were isolated from urine samples of 15 patients, with E. coli being the most prevalent.
JOURNAL OF NEUROTRAUMA, 2010 • February 1, 2010
This study compared behavioral and histological outcomes in male and female NOD-SCID, C57BL=6, and BUB=BnJ mice after spinal cord injury. NOD-SCID mice scored higher on an open-field locomotor task tha...
KEY FINDING: NOD-SCID mice exhibited the greatest locomotor recovery in the open field compared to C57BL/6 and BUB/BnJ mice.
J Spinal Cord Med, 2009 • November 1, 2009
This study evaluated the validity, accuracy, and predictive value of UTI signs and symptoms in individuals with SCI on IC. It also assessed the accuracy of individuals with SCI on IC at predicting the...
KEY FINDING: Cloudy urine had the highest accuracy (83.1%) in predicting UTI, while leukocytes in the urine showed the highest sensitivity (82.8%).