Immunology Research

KEY FINDING: Significant improvements in forelimb function were observed one week post-injury in the group treated with PEGylated IFN-β, but these improvements were not sustained long-term.

KEY FINDING: Mice deficient in factor B (fB), a protein in the alternative complement pathway, were protected from traumatic SCI, showing reduced tissue damage, demyelination, and inflammatory cell infiltrate.

KEY FINDING: PRDX6 transgenic (Tg) mice displayed a significant decrease in clinical severity and attenuated demyelination in EAE compared to wide type mice.

KEY FINDING: Conditioned media from polymorphonuclear leukocytes (PMN) selectively increased hNSC astrogliogenesis and promoted cell migration in vitro.

KEY FINDING: Inpatient culture, male gender, sputum and other specimen type, receipt of antibiotics within 90 days before culture date, and pressure ulcers were identified as independent predictors of MDR Acinetobacter.

KEY FINDING: Foul smelling urine had the highest sensitivity (0.50, 95% CI: 0.31-0.69) for UTI diagnosis.

KEY FINDING: C3−/− mice demonstrated a 2-fold increase in sensory axon regeneration in the spinal cord compared to wildtype C3+/+ mice 6 weeks after dorsal hemisection with peripheral conditioning lesion.

KEY FINDING: Most positive urine cultures from SCI annual evaluations represented ASB cases.

KEY FINDING: Low-intensity treadmill exercise improved neuropathic pain behaviors in mice, including mechanical hyperalgesia, escape/avoidance behavior, and spontaneous locomotor activity.

KEY FINDING: People with SCI showed lower proportions of naïve T-cells and more memory T-cells compared to age-matched controls, indicating a shift towards an older immune profile.