Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 151-160 of 620 results
Neurology, 2017 • February 28, 2017
This longitudinal cohort study investigated the impact of hospital-acquired pneumonia and wound infections (Pn/Wi) on long-term outcomes after acute traumatic spinal cord injury (SCI). The study found...
KEY FINDING: Hospital-acquired pneumonia or wound infections (Pn/Wi) are significantly associated with lower gain in motor function (FIMmotor) up to 5 years after SCI.
BMC Infectious Diseases, 2016 • April 4, 2016
This retrospective study evaluated the impact of antibiotic treatment duration and monotherapy versus dual therapy on the cure rate of febrile UTIs in patients with neurogenic bladder. The study found...
KEY FINDING: There was no statistically significant difference in cure rates between the three antibiotic treatment duration groups (<10 days, 10-15 days, >15 days).
Spinal Cord, 2017 • July 1, 2017
This retrospective cohort study identified risk factors associated with community-associated multidrug resistant Pseudomonas aeruginosa (MDRPA) in Veterans with spinal cord injury and disorders (SCI/D...
KEY FINDING: Patients aged 50-64 years had a significantly higher risk of MDRPA compared to younger patients (18-49 years).
PLOS ONE, 2017 • February 7, 2017
This study aimed to define the role of nucleic acid sensors triggering innate immune response from SCI PBMC. The researchers found that SCI patients with level of injury above T-6 displayed impaired T...
KEY FINDING: SCI patients’ B-cell and plasmacytoid dendritic cells retain their functionality in response to TLR7 and TLR9 ligand stimulation as they secreted similar levels of IL6 and IFNα compared to healthy controls.
Int. J. Mol. Sci., 2022 • September 29, 2022
This study examined the temporal profile of circulating white blood cells during the progression of DCM in a mouse model. The research aimed to identify potential systemic hematological changes that c...
KEY FINDING: Circulating monocytes increased four-fold at 3 weeks following DCM induction, but these differences normalized at subsequent time points.
J Spine Surg, 2015 • December 1, 2015
A total of 582 patients with TB of the cervical, thoracic and lumbar spine with moderate to severe cord compression were studied. Variable degrees of neurological deficit with deformity were treated f...
KEY FINDING: Neurological improvement occurred in all patients except for 2 cases (0.3%).
Drug Design, Development and Therapy, 2020 • December 4, 2020
This study investigates the effect of sanguinarine (SG) on chronic constriction injury (CCI)-induced neuropathic pain (NP) in rats. SG is a natural plant medicine known for its anti-inflammatory and n...
KEY FINDING: Sanguinarine (SG) treatment increased paw withdrawal mechanical threshold (PWT) and thermal withdrawal latency (TWL) in CCI rats, indicating reduced mechanical sensitivity and heat hypersensitivity.
TheScientificWorldJOURNAL, 2006 • February 17, 2006
The objective of this article was to determine the current practice on amikacin dosing and monitoring in spinal cord injury patients from spinal cord physicians and experts. This study shows that ther...
KEY FINDING: Clinical practice varies considerably across spinal units regarding amikacin administration, with some using once-daily dosing and others using divided doses.
Spinal Cord Series and Cases, 2017 • May 11, 2017
This case report describes the successful use of ceftolozane/tazobactam (C/T) to treat a febrile urinary tract infection (UTI) caused by multidrug-resistant (MDR) Pseudomonas aeruginosa (PSA) in a 35-...
KEY FINDING: Ceftolozane/tazobactam was effective in treating a febrile UTI caused by multidrug-resistant Pseudomonas aeruginosa in a patient with a neurogenic bladder.
J Spinal Cord Med, 2006 • January 1, 2006
This randomized, double-blind study evaluated the efficacy of bladder irrigation with saline, acetic acid, or neomycin-polymyxin in treating bacteriuria in persons with neurogenic bladder. The study f...
KEY FINDING: No significant reduction in bacteriuria was observed with any of the three irrigants (saline, acetic acid, neomycin-polymyxin).