Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 401-410 of 620 results
PNAS, 2001 • December 18, 2001
This study investigates the effect of posttraumatic immunization with a peptide derived from Nogo-A (p472) on recovery from spinal cord injury in rats. The study found that immunization with p472 redu...
KEY FINDING: Posttraumatic immunization with p472, a peptide derived from Nogo-A, substantially reduced neuronal degeneration and promoted recovery after incomplete spinal-cord contusion in rats.
CMLS Cellular and Molecular Life Sciences, 2003 • January 1, 2003
This study investigates the role of MT-I+II in EAE-induced demyelination, neurodegeneration, and axonal injury, as well as their influence on neuroglial regeneration and growth factor expression. The ...
KEY FINDING: MT-I+II deficiency significantly increases demyelination in mice with EAE. This was determined by loss of MBP staining in the brain stem, spinal cord, and cerebellum.
American Journal of Pathology, 2003 • September 1, 2003
This study investigates the role of complement C5 in EAE, comparing C5-deficient and C5-sufficient mice. While both groups initially displayed similar clinical courses, significant histopathological d...
KEY FINDING: In C5-deficient mice, lesions were restricted and characterized by a delay in inflammatory cell infiltration and tissue damage during acute EAE.
The Journal of Neuroscience, 2003 • September 24, 2003
This study demonstrates that vaccination with DCs pulsed with MBP-derived peptides promotes functional recovery from spinal cord injury in rats. The DC-mediated neuroprotection is achieved via the ind...
KEY FINDING: Local or systemic injection of DCs pulsed with MBP-derived peptides significantly improved locomotor function in rats after spinal cord injury.
Brain Pathol, 2003 • January 1, 2003
This study investigates the structural requirements of IgM antibodies sHIgM22 and 94.03 in promoting CNS myelin repair, using the TMEV model of MS. The study aims to determine whether the constant reg...
KEY FINDING: Antibody sHIgM22 retained its function of promoting remyelination even when reduced to a bivalent F(ab’)2 fragment, indicating that the Fc region and pentameric structure of IgM are not always necessary for myelin repair.
PLoS Medicine, 2007 • April 10, 2007
The study investigates the potential of TREM2-transduced myeloid precursor cells to mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis (EAE). Resu...
KEY FINDING: TREM2-transduced myeloid cells migrated to inflammatory lesions in the spinal cord of EAE mice.
Exp Neurol, 2008 • February 1, 2008
Inflammation following SCI has been shown to have both pathogenic and pivotal roles in tissue repair. A challenge for researchers is to learn how to control cross-talk between the nervous and immune s...
KEY FINDING: The inflammatory response in the brain differs from that in the spinal cord in terms of timing, composition, and magnitude.
Neuroscience, 2009 • February 6, 2009
Traumatic SCI triggers autoimmune reactions involving T and B cells, influencing post-traumatic inflammation, neurodegeneration, and repair processes. These lymphocytes are activated by SCI and play s...
KEY FINDING: SCI activates MBP-reactive T cells capable of causing neuroinflammation and transient paralysis in rats, and the frequency of MBP-reactive T cells increases in SCI humans, reaching levels that approximate those seen in MS patients.
PLoS Medicine, 2008 • August 19, 2008
This study investigates the role of chondroitin sulfate proteoglycan (CSPG) in spinal cord repair, challenging the common belief that it's solely detrimental. The research hypothesizes and demonstrate...
KEY FINDING: Immediate inhibition of CSPG synthesis after spinal cord injury impairs functional motor recovery and increases tissue loss, indicating a beneficial role for CSPG during the acute phase.
The Journal of Neuroscience, 2008 • September 17, 2008
This study demonstrates the critical role of CD11b+ myeloid cells in axon regeneration after neural injury, using a transgenic mouse model for selective cell ablation. The absence of CD11b+ cells lead...
KEY FINDING: Selective ablation of CD11b+ cells impairs axonal regeneration and locomotor function recovery after sciatic nerve injury.