Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 391-400 of 620 results
Nat Immunol, 2020 • December 1, 2020
The study identifies a novel myeloid cell phenotype with neuroprotective and axonogenic properties that arises in the setting of optic nerve and spinal cord injury. This reparative cell is a CD14+Ly6G...
KEY FINDING: A unique granulocyte subset, characterized as an immature neutrophil, exhibits neuroprotective properties and drives CNS axon regeneration in vivo.
Front. Aging Neurosci., 2020 • September 23, 2020
This review explores the role of the adaptive immune system in neurodegenerative diseases, highlighting its involvement in both degeneration and regeneration processes. Aging is identified as a key fa...
KEY FINDING: Adaptive immune cells, particularly T lymphocytes, can have both detrimental and beneficial roles in neurodegenerative diseases, influencing both degeneration and regeneration.
Clin. Transl. Med., 2021 • December 29, 2020
This study investigates the role of CD73 in alleviating GSDMD-mediated microglia pyroptosis in spinal cord injury (SCI) through the PI3K/AKT/Foxo1 signaling pathway. The research demonstrates that CD7...
KEY FINDING: CD73 suppresses the activation of NLRP3 inflammasome complexes to reduce the maturation of GSDMD, leading to decreased pyroptosis in microglia.
Nat Neurosci, 2021 • February 1, 2021
This study demonstrates the presence of a fibrotic scar in the CNS following immune cell infiltration in a mouse model of multiple sclerosis, suggesting a common response to injury and inflammation ac...
KEY FINDING: A robust Col1+ fibrotic scar forms in response to immune cell infiltration in the CNS, specifically in neuroinflammatory lesions.
Front. Aging Neurosci., 2021 • February 9, 2021
This study investigated the role of immune cell infiltration in Parkinson's disease (PD) by analyzing transcriptomic datasets from the substantia nigra of PD patients and healthy controls. The study i...
KEY FINDING: The study identified 10 types of immune cells with significantly different infiltration levels between PD patients and healthy controls, including activated B cells, CD56 bright natural killer cells, and mast cells.
Frontiers in Immunology, 2021 • February 19, 2021
This study examined the impact of individual TnC fragments on astrocytic physiology in vitro and in vivo after spinal cord injury (SCI). The results indicated that TnC fragments delay gap closure in v...
KEY FINDING: TnC fragments delay gap closure in astrocyte cultures, primarily by reducing astrocyte proliferation. The most potent fragments were FnD, FnA, and their combination.
Theranostics, 2021 • February 20, 2021
This study investigates the role of SARM1 in spinal cord injury (SCI) using conditional knockout mice. The researchers found that SARM1 is upregulated in neurons and astrocytes after SCI, promoting ne...
KEY FINDING: SARM1 was upregulated in neurons and astrocytes at the early stage after SCI.
Journal of Neuroinflammation, 2021 • March 23, 2021
The study investigates the role of CRYAB, a small heat shock protein, in the immune response following peripheral nerve injury, focusing on macrophages. Results show that Cryab−/− mice exhibit a prolo...
KEY FINDING: More pro-inflammatory CD16/32+ macrophages are present in the nerves of Cryab−/− mice at days 14 and 21 after sciatic nerve crush-injury compared to WT counterparts.
International Journal of Molecular Sciences, 2021 • March 9, 2021
This study investigates the effects of montelukast (MTK), a leukotriene receptor antagonist, on neuroinflammation and cognition in 5xFAD mice, a model for Alzheimer's disease (AD). The results showed ...
KEY FINDING: MTK treatment modulated glial activation and neuroinflammation pathways in 5xFAD mice. The treatment increased Tmem119+ microglia and downregulated genes related to AD-associated microglia.
The Journal of Neuroscience, 2001 • July 1, 2001
This study investigates the molecular mechanisms controlling rapid myelin phagocytosis in the adult mouse spinal cord after LPC-induced demyelination. It focuses on identifying key chemokines and cyto...
KEY FINDING: The study found that mRNA expression of MIP-1a, MCP-1, GM-CSF, and TNF-a in the spinal cord is rapidly and transiently upregulated after intraspinal injection of LPC.