Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 71-80 of 620 results
Spinal Cord Series and Cases, 2021 • June 1, 2021
This study examined the impact of a high-fat/high-carbohydrate (HFHC) meal on circulating immune cell numbers in individuals with chronic spinal cord injury (SCI). Contrary to the hypothesis, immune c...
KEY FINDING: A significant time × condition interaction effect was observed in CD3+, CD4+, and CD8+ T cells, as well as CD56+ and CD3+/CD56+ natural killer (NK) cells.
Journal of Neuroinflammation, 2021 • January 1, 2021
This study identifies D-DT as a novel inflammatory activator of astrocytes following spinal cord injury, suggesting it could be a beneficial target for anti-inflammation drug development in neuropatho...
KEY FINDING: D-DT expression is induced in astrocytes and neurons, but not microglia, following spinal cord contusion, indicating a cell-specific response to injury.
Annals of Rehabilitation Medicine, 2021 • June 14, 2021
This study evaluated the risk of post-urodynamic study (UDS) urinary tract infection (UTI) in spinal cord injury (SCI) patients with pre-UDS pyuria. The study found no statistically significant differ...
KEY FINDING: The study found no statistically significant difference in the prevalence of post-UDS UTI between patients with and without pyuria before the UDS.
World Journal of Clinical Cases, 2021 • June 6, 2021
This case report discusses a 45-year-old woman with NMOSD, Sjogren's syndrome, spinal cord injury, and deep venous thrombosis who underwent rehabilitation and pharmacotherapy. The patient's condition ...
KEY FINDING: The patient with NMOSD, spinal cord injury, Sjogren's syndrome, and deep venous thrombosis showed considerable improvement after rehabilitation and pharmacotherapy.
Journal of Neuroinflammation, 2021 • May 7, 2021
The study aimed to elucidate the system-wide changes induced by minocycline treatment in a rodent model of cervical SCI, focusing on the microbiota-immune axis and behavioral outcomes. Minocycline tre...
KEY FINDING: Minocycline had a profound acute effect on the microbiota diversity and composition, which was paralleled by the subsequent normalization of spinal cord injury-induced suppression of cytokines/chemokines.
Muscle & Nerve, 2021 • July 9, 2021
This letter describes the COVID-19 prevalence and case fatality rate (CFR), as reported by aggregate summaries from VINCI, as well as the characteristics and outcomes, as reported by the VHA-SCI/D Reg...
KEY FINDING: Veterans with ALS were 3.0 times more likely to die within 30 days of a COVID-19 diagnosis compared to the overall veteran population (CI: 1.9–4.9, p < .001).
Spinal Cord, 2021 • August 17, 2021
This review indicates a similar rate of COVID-19 Vaccine breakthrough in individuals with SCI/D compared to residents of SNFs in which frequent surveillance testing is occurring. The predominance of a...
KEY FINDING: COVID-19 vaccine breakthrough was identified in 17 out of 8319 (0.20%) of fully vaccinated Veterans with SCI/D as of April 20, 2021.
Frontiers in Immunology, 2021 • August 11, 2021
This study demonstrates that infiltrated neutrophils produce NETs at the injury site, exacerbating secondary injury in SCI by promoting neuroinflammation and disrupting the blood-spinal cord barrier. ...
KEY FINDING: Infiltrated neutrophils produce NETs at the epicenter of the SCI, which contributes to secondary injury.
BMC Infect Dis, 2021 • September 15, 2021
The study evaluated SARS-CoV-2 antibody prevalence and asymptomatic infection rates among Austrian hospital staff. Key findings include a low seroprevalence (0.82%), a significant proportion of asympt...
KEY FINDING: Only 0.82% of participants had positive antibodies confirmed via neutralization test during the study.
Surgical Neurology International, 2021 • August 30, 2021
This case report describes the successful use of aneurysm clips to repair a cisterna chyli (CC) injury sustained during a thoracolumbar fusion. This technique has not been previously described in lite...
KEY FINDING: Aneurysm clips can be safely and effectively used to repair cisterna chyli injuries during spinal surgery.