Browse the latest research summaries in the field of mental health for spinal cord injury patients and caregivers.
Showing 211-220 of 290 results
Top Spinal Cord Inj Rehabil, 2015 • January 1, 2015
This study investigated the relationships between adult romantic attachment, perceived social support, depression, and resilience in individuals with SCI undergoing inpatient rehabilitation. The resea...
KEY FINDING: Individuals with higher levels of attachment avoidance have lower perceived social support, which in turn relates to lower perceived resilience.
Translational Psychiatry, 2021 • April 19, 2021
This study investigates the acute effects of therapeutic and overdose concentrations of lithium on human iPSC-derived cortical neurons using MEA and patch-clamp techniques. The findings reveal that th...
KEY FINDING: Therapeutic concentrations of lithium increase neuronal excitability and network activity in human iPSC-derived cortical neurons.
Molecular Psychiatry, 2022 • July 7, 2022
Using serum samples from a longitudinal, population-based ageing cohort, we provide evidence to support that blood-borne factors, via the systemic milieu of participants, influence the fate of hippocam...
KEY FINDING: Reduced cell death and increased neuronal differentiation were associated with later life depressive symptomatology.
Frontiers in Psychiatry, 2022 • August 23, 2022
This study used integrated co-expression network analysis to identify tissue-specific gene modules and functions in major depressive disorder (MDD) and bipolar disorder (BP). The analysis revealed nin...
KEY FINDING: Nine tissue-specific modules were identified in MDD across four tissues, and six modules in BP.
International Journal of Surgery, 2024 • September 26, 2023
This systematic review and network meta-analysis evaluated the effectiveness of nonpharmacological interventions for reducing psychological symptoms in patients with chronic low back pain (CLBP). The ...
KEY FINDING: Mind body therapy, biopsychosocial approach, and physical therapy were effective in reducing depression compared to the control group.
The Journal of Spinal Cord Medicine, 2015 • January 1, 2015
The study aimed to assess the differences in functional activity, perceived health, and depressive symptoms between individuals with traumatic paraplegia with and without shoulder pain. The results in...
KEY FINDING: Shoulder pain was prevalent in 30% of patients with traumatic paraplegia.
Neural Regeneration Research, 2021 • March 1, 2021
This study investigates the antidepressant effects of solid lipid nanoparticles loaded with curcumin and dexanabinol in a mouse model of major depressive disorder. The results demonstrate that the nan...
KEY FINDING: Solid lipid nanoparticles loaded with curcumin and dexanabinol increased the mRNA and protein expression levels of mature neuronal markers (NeuN, MAP2, Tuj1) in wild-type mice.
Journal of Clinical Medicine, 2020 • December 18, 2020
The study aimed to identify cellular phenotypes in ADHD patient-derived cellular models from carriers of rare copy number variants (CNVs) in the PARK2 locus. Human-derived fibroblasts (HDF) and human-...
KEY FINDING: Changes were found in PARK2 gene and protein expression in PARK2 CNV deletion and duplication carriers with ADHD compared to controls.
BioMed Research International, 2014 • May 14, 2014
This review discusses the structure and function of chondroitin sulfate proteoglycans (CSPGs) in both healthy states and in the context of genetic disorders affecting the brain. The reviewed studies h...
KEY FINDING: Genetic variation in the NCAN gene (rs1064395) is a common risk factor for bipolar disorder and schizophrenia.
Neural Plasticity, 2014 • May 22, 2014
The review explores the link between hippocampal neurogenesis and the action of antidepressant therapies, particularly ECT. While speculations about this connection have existed for over a decade, con...
KEY FINDING: Experimental ECS enhances neurogenesis in various species. A close relationship exists between hippocampal function and mood regulation.