Neurology Research
Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 141-150 of 5,401 results
Blood–spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis
Acta Neuropathol, 2013 • September 1, 2012
This study demonstrates BSCB disruption in ALS patients, leading to erythrocyte extravasation and accumulation of erythrocyte-derived products in the spinal cord. The research also found an associatio...
KEY FINDING: ALS patients exhibit perivascular deposits of erythrocyte-derived hemoglobin and hemosiderin in the cervical spinal cord.
Selective Corticospinal Tract Injury in the Rat Induces Primary Afferent Fiber Sprouting in the Spinal Cord and Hyperreflexia
The Journal of Neuroscience, 2012 • September 12, 2012
The study demonstrates that selective CST injury induces maladaptive afferent fiber plasticity remote from the lesion, suggesting a novel structural reaction of proprioceptive afferents to the loss of...
KEY FINDING: Selective CST injury induces proprioceptive afferent plasticity in the spinal cord, leading to sprouting of afferent fibers into denervated gray matter regions.
Effect of PACAP in Central and Peripheral Nerve Injuries
Int. J. Mol. Sci., 2012 • July 6, 2012
This review summarizes findings on the neuroprotective potential of PACAP in models of different traumatic nerve injuries, highlighting its role in neuronal regeneration. Endogenous PACAP and its rece...
KEY FINDING: Expression of endogenous PACAP and its specific PAC1 receptor is elevated in different parts of the central and peripheral nervous system after traumatic injuries.
Allografts of the Acellular Sciatic Nerve and Brain-Derived Neurotrophic Factor Repair Spinal Cord Injury in Adult Rats
PLoS ONE, 2012 • August 28, 2012
This study investigates the efficacy of acellular sciatic nerve (ASN) combined with brain-derived neurotrophic factor (BDNF) in repairing spinal cord injury (SCI) in adult rats. The results suggest th...
KEY FINDING: Transplantation of ASN-BDNF shows promise for neuron regeneration.
Motoneuron Replacement for Reinnervation of Skeletal Muscle in Adult Rats
J Neuropathol Exp Neurol, 2012 • October 1, 2012
This study investigated whether transplanting a purified population of embryonic motoneurons into peripheral nerve resulted in more motor units and reinnervation than transplanting a mixed population ...
KEY FINDING: Transplanting more motoneurons did not increase motoneuron survival, and the number of transplanted motoneurons or their survival did not limit muscle reinnervation.
MHC mismatch results in neural progenitor cell rejection following spinal cord transplantation in a model of viral-induced demyelination
Stem Cells, 2012 • November 1, 2012
This study demonstrates that allogeneic NPCs are rejected following transplantation into the inflamed CNS of JHMV-infected mice due to T cell-mediated immune responses. The research highlights that al...
KEY FINDING: Allogeneic NPCs are antigenic and induce a delayed-type hypersensitivity (DTH) response, indicating T cell involvement.
A novel compound, denosomin, ameliorates spinal cord injury via axonal growth associated with astrocyte-secreted vimentin
British Journal of Pharmacology, 2013 • February 1, 2013
This study investigates the effects of denosomin on functional recovery in SCI mice and elucidates the mechanism through which denosomin induces axonal growth in the injured spinal cord. The key findi...
KEY FINDING: Denosomin improves motor dysfunction and axonal growth, especially in 5-HT-positive tracts across the scar, and increases astrocyte density in SCI mice.
Long-Distance Growth and Connectivity of Neural Stem Cells After Severe Spinal Cord Injury
Cell, 2012 • September 14, 2012
Neural stem cells (NSCs) expressing GFP were embedded into fibrin matrices containing growth factor cocktails and grafted to sites of severe spinal cord injury. Grafted cells differentiated into multi...
KEY FINDING: Neural stem cells, when grafted into sites of complete spinal cord transection, differentiated into neurons and extended axons over remarkably long distances (up to 25 mm) in both rostral and caudal directions.
Dependence of Regenerated Sensory Axons on Continuous Neurotrophin-3 Delivery
The Journal of Neuroscience, 2012 • September 19, 2012
The study examined the necessity of continuous NT-3 delivery for sustaining regenerated sensory axons in injured spinal cords using a tetracycline-regulated lentiviral gene delivery system in rats. Re...
KEY FINDING: Regenerated sensory axons require continuous NT-3 delivery for sustained growth and survival in the injured spinal cord.
Exogenous BDNF enhances the integration of chronically injured axons that regenerate through a peripheral nerve grafted into a chondroitinase-treated spinal cord injury site
Exp Neurol, 2013 • January 1, 2013
The study investigated whether exogenous BDNF could enhance axonal regeneration beyond a ChABC-treated glial interface in a chronic spinal cord injury model using peripheral nerve grafts (PNGs). While...
KEY FINDING: ChABC treatment alone promoted axonal regeneration beyond the graft-host interface.