Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 41-50 of 5,253 results
Ann Neurol., 2023 • June 1, 2023
This study demonstrates that novel, noninvasive, Hebbian stimulation tailored to induce plasticity at corticospinal-motoneuronal synapses at multiple sites in the spinal cord, combined with exercise t...
KEY FINDING: Participants receiving Hebbian stimulation improved their walking speed and corticospinal function to a greater extent than individuals receiving sham stimulation.
CNS Neurosci Ther, 2023 • January 1, 2023
This study investigates the role of bile acids and their receptors, TGR5 and FXR, in alleviating neuropathic pain induced by spared nerve injury (SNI) in mice. The results demonstrate that SNI leads t...
KEY FINDING: Bile acid levels are decreased in the spinal dorsal horn after spared nerve injury (SNI), while CYP7A1 expression is upregulated in microglia.
Cellular and Molecular Neurobiology, 2023 • March 13, 2023
This study investigates the therapeutic potential of inhibiting Chst15, an enzyme controlling the biosynthesis of inhibitory chondroitin sulfate-E (CS-E), for spinal cord injury (SCI) treatment. The r...
KEY FINDING: Inhibition of Chst15 impairs the deposition of CSPGs in the extracellular matrix and the migration of astrocytes, which are key processes in glial scar formation after SCI.
Neural Regen Res, 2023 • January 30, 2023
The study investigated the role of serum response factor (SRF) in axon regeneration following spinal cord transection injury in rats. The researchers found that SRF expression increased after SCI and ...
KEY FINDING: SRF expression in injured spinal cord gray matter neurons gradually increased, peaking on the 7th day after injury.
Neural Regeneration Research, 2023 • January 5, 2023
The study investigates the role of gecko HSF1 (gHSF1) in regulating neurite outgrowth and inflammatory inhibition of macrophages following spinal cord injury using a gecko model. Results showed that g...
KEY FINDING: gHSF1 expression in neurons and microglia at the lesion site increased dramatically immediately after tail amputation.
Redox Biology, 2023 • March 20, 2023
This study elucidates the protective role of Git1 in spinal cord ischemia-reperfusion injury (SCIRI), demonstrating that Git1 deletion impairs functional recovery in mice. The research uncovers a nove...
KEY FINDING: Deletion of Git1 in mice resulted in poorer recovery of spinal cord motor function after SCIRI, indicating Git1's protective role.
The Journal of Spinal Cord Medicine, 2023 • July 1, 2023
The study evaluated the effects of midodrine on blood pressure (BP) in hypotensive individuals with spinal cord injury (SCI) during a 30-day home monitoring period. Midodrine increased average BP and ...
KEY FINDING: Midodrine significantly increased average 30-day systolic and diastolic blood pressure compared to placebo.
Medicine, 2023 • March 10, 2023
This case report details a rare presentation of inferior STEMI combined with hyperextension cervical spine injury in a 70-year-old male. The patient presented with syncope, chest tightness, and neurol...
KEY FINDING: The patient was diagnosed with inferior STEMI combined with hyperextension cervical spine injury, a rare and challenging clinical presentation.
Spinal Cord Series and Cases, 2023 • March 16, 2023
This pilot study provides evidence that FEST can improve muscle strength and activation in individuals with SCI, accompanied by electrophysiological changes. FEST might enhance sensory-motor integrati...
KEY FINDING: FEST can lead to gains in muscle strength and activation in individuals with SCI, indicating the activation of more motor units and faster motor units.
Therapeutic Advances in Neurological Disorders, 2023 • February 14, 2023
This review provides an overview of locked-in syndrome (LiS), covering its anatomy, pathophysiology, treatments, quality of life, and ethical considerations. It discusses the different structures affe...
KEY FINDING: The review highlights the anatomical foundations of LiS and LiPS, discussing the structures in the pons, mesencephalon, and thalamus that can be affected. Damage to these areas can result in classical, complete, and incomplete LiS, as well as LiPS, which includes impairments of consciousness.