Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 4,971-4,980 of 5,253 results
J Neurol Phys Ther, 2007 • March 1, 2007
This study examined neuromuscular control of the knee joint during a single leg squat (SLS) task, where participants tracked a sinusoidal target at a normalized resistance level. The study found that ...
KEY FINDING: Individuals increased the accuracy of performance in each trial and retained this improvement across trials.
Spinal Cord, 2016 • September 1, 2015
The RHI-ISNCSCI Algorithm was developed and validated as a computerized tool to improve the accuracy and standardization of spinal cord injury classification according to the ISNCSCI standards. The al...
KEY FINDING: The RHI-ISNCSCI Algorithm provides a standardized method to accurately derive the level and severity of SCI from the raw data of the ISNCSCI examination.
Nat Med, 2017 • June 1, 2017
This study demonstrates that pericytes play a major role in regulating capillary tone and blood flow in the spinal cord after SCI, leading to chronic hypoxia. The researchers found that AADC expressed...
KEY FINDING: SCI leads to chronic hypoxia in the spinal cord below the injury site due to excessive capillary tone.
Frontiers in Neurology, 2016 • November 15, 2016
The glial scar has been synonymous with reactive astrocytes, but there is substantial evidence indicating that NG2 cells are also a major part of the glial scar, both physically and functionally. Simi...
KEY FINDING: NG2 cells are a major component of the glial scar after SCI and share functional overlap with astrocytes in this region.
The Journal of Neuroscience, 2008 • November 12, 2008
The study demonstrates that degrading CSPGs with ChABC can promote the reorganization of spinal circuitry and restore sensory function after partial deafferentation. Electrophysiological recordings co...
KEY FINDING: ChABC normalizes deafferentation-induced compromise of sensory function. Spared-root-lesioned animals treated with ChABC did not show a deficit in their ability to sense the presence of the tape or the ability to remove the tape on any of the postinjury testing days.
Journal of Cerebral Blood Flow & Metabolism, 2015 • January 28, 2015
This study investigates the impact of hypoxia-ischemia (HI) on the blood-brain barrier (BBB) and cerebral blood flow (CBF) in neonatal mice, aiming to understand mechanisms leading to perinatal brain ...
KEY FINDING: Hypoxia-ischemia increased BBB permeability to small and large molecules within hours after the insult, which normalized in the following days.
The Journal of Neuroscience, 2011 • March 23, 2011
This study demonstrates that neural progenitor cells (NPCs) can be used to create a neuronal relay across the injured spinal cord, forming synaptic connections with host neurons and restoring function...
KEY FINDING: Neural progenitor cells can be grafted into the injured spinal cord to form a neuronal relay by extending axons across the injury site.
The Journal of Comparative Neurology, 2012 • February 8, 2012
This study aimed to evaluate the effects of post-SCI administration of 17b-estradiol on functional recovery and histopathology in a cervical model of SCI. The researchers found that post-SCI administr...
KEY FINDING: Post-SCI administration of 17b-estradiol decreased neuronal loss in the ventral horn, suggesting a neuroprotective effect.
Frontiers in Cellular Neuroscience, 2016 • February 9, 2016
This study challenges the dogma that the CNS is an alymphatic environment by investigating the expression of lymphatic markers LYVE-1 and PROX1 in the adult rat spinal cord. The research identified nu...
KEY FINDING: PROX1-immunoreactivity was detected in numerous nuclei evenly distributed throughout the gray and white matter of the rat adult spinal cord.
Neural Regen Res, 2013 • June 1, 2013
This study investigated the effects of X-irradiation on glial scar formation and functional recovery in rats with spinal cord injury. The researchers aimed to determine the optimal time window for X-i...
KEY FINDING: X-irradiation at 8 Gy reduced the expression of macrophage marker ED-1, indicating a decrease in inflammation.