Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 5,141-5,150 of 5,253 results
Front. Behav. Neurosci., 2015 • October 21, 2015
This study investigates the conditions under which fixed time (FT) stimulation has a transformative effect on spinal learning in spinally transected rats, focusing on the number of shocks and the dura...
KEY FINDING: The restorative effect of fixed time (FT) stimulation on spinal learning emerges after 540 shocks in spinally transected rats.
The Journal of Neuroscience, 1985 • June 1, 1985
This study demonstrates that certain neurons in the adult rat olfactory bulb (OB) can regrow axons along peripheral nerve grafts, indicating a regenerative capacity within the mammalian CNS. The resea...
KEY FINDING: OB axons extending along peripheral nerve grafts originate from mitral and tufted cells near the graft tip, not from smaller OB neurons.
Annu Rev Psychol, 2010 • January 1, 2010
Cognitive neural prosthetics (CNPs) tap into higher brain functions beyond motor commands or sensory signals, encompassing intention, planning, attention, decision-making, executive control, emotions,...
KEY FINDING: Intended goals can be decoded from prefrontal and parietal regions, allowing for rapid applications like 'typing' using letter boards.
Frontiers in Cellular Neuroscience, 2016 • January 20, 2016
Platelets are not restricted to haemostasis; they regulate inflammation, angiogenesis, and tissue repair. Neuroinflammation is relevant for CNS repair as it contributes to debris clearance and control...
KEY FINDING: Platelets accumulate in the subventricular zone (SVZ) vasculature upon demyelination, which is associated with enhanced survival of SVZ-resident neural stem cells (NSCs).
J Spinal Cord Med, 2007 • January 1, 2007
The purpose of this study is to report the results of rater agreement for the International Standards for Neurological Classification of Spinal Cord Injury (ISCSCI) motor and sensory scores before and...
KEY FINDING: Training improved rater agreement of summed motor scores (MS) from ICC ¼0.809 to 0.862 and discrimination scores from ICC¼0.786 to 0.892.
Journal of Biomedical Materials Research Part A, 2018 • April 25, 2018
This study evaluates the effectiveness of a neurotrophin-3 (NT-3) releasing scaffold in treating spinal cord injury (SCI) in canines. The scaffold was designed to inhibit inflammation, promote nerve f...
KEY FINDING: The NT-3/fibroin scaffold (NF-GS) significantly improved hindlimb locomotion in canines with spinal cord injury compared to a control group (F-GS).
The Journal of Neuroscience, 2017 • November 8, 2017
This study investigates the effects of post-injury ErbB2 activation in Schwann cells (SCs) on dorsal root (DR) axon regeneration using a doxycycline-inducible transgenic mouse line. The results demons...
KEY FINDING: Post-injury induction of caErbB2 in SCs selectively hyperactivates denervated, but not innervated, SCs, increasing their proliferation and prolonging their dedifferentiation.
Brain Sci., 2018 • December 16, 2018
The present study examined bilateral cortical organization in individuals with chronic incomplete cervical SCI and uninjured controls. Several novel findings were revealed that provide new information ...
KEY FINDING: Muscle representations in SCI are shifted medially compared to controls.
Front. Neurosci., 2025 • January 7, 2025
Mitochondria, supplying most ATP through oxidative phosphorylation, produce mtROS byproducts that can act as molecular signals or cause cell death. Maintaining a healthy mitochondrial state involves m...
KEY FINDING: Mitochondrial protein acetylation, particularly through enzymes like GCN5L1 and Sirt3, plays a significant role in neuronal activity and the pathophysiology of cerebral injury. Sirt3, for example, regulates processes such as mPTP opening, mitochondrial dynamics, and mitophagy, protecting mitochondrial function and preventing neuronal death in ischemic stroke.
J Neurophysiol, 2006 • April 1, 2006
This study examined the effects of long-term neuromuscular electrical stimulation (NMES) training on musculoskeletal health in individuals with acute spinal cord injury (SCI). The primary outcomes wer...
KEY FINDING: Long-term NMES training resulted in significant improvements in plantar flexor muscle properties, including increased peak torque (+24%), torque-time integral (+27%), fatigue index (+50%), and torque rise time (+45%).