Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 5,151-5,160 of 5,253 results
International Journal of Molecular Sciences, 2022 • March 15, 2022
This review highlights the potential of sovateltide, a selective ETBRs agonist, as a therapeutic candidate for neurological disorders. Preclinical and clinical studies suggest its safety and efficacy ...
KEY FINDING: Sovateltide has shown promise in preclinical studies for treating cerebral stroke, Alzheimer's disease, spinal cord injury, and neonatal hypoxic-ischemic encephalopathy by promoting neuroprotection and neuroregeneration.
Front. Cell. Neurosci., 2016 • March 4, 2016
This study presents an in vitro approach to assess the influence of human cerebrospinal fluid (hCSF) on neuronal circuits by examining survival, morphology, and network properties of hippocampal neuro...
KEY FINDING: hCSF increases neuronal viability and the number of electrophysiologically active neurons compared to standard culture media in rat hippocampal slices and primary neurons.
J Rehabil Res Dev, 2008 • January 1, 2008
Stroke is a major cause of disability, and muscle abnormalities in the contralateral leg may contribute to this disability. These abnormalities include muscle atrophy, altered contractile protein expr...
KEY FINDING: Contralateral leg muscle shows atrophy compared to the ipsilateral leg in chronic stroke patients.
JOURNAL OF VIROLOGY, 1999 • July 1, 1999
This study demonstrates that poliovirus (PV) infection in mice leads to apoptosis in the central nervous system (CNS), contributing to the paralysis observed in poliomyelitis. Both neurovirulent and a...
KEY FINDING: PV infection causes cleavage of DNA into nucleosomes in the mouse CNS, indicating apoptosis.
eNeuro, 2015 • March 26, 2015
The study introduces optimized methods for visualizing traced axons in cleared spinal cords from transgenic and nontransgenic animals, comparing different AAV serotypes, promoters, and fluorescent pro...
KEY FINDING: AAV8 serotype with UbC promoter expressing GFP provides the strongest fluorescence signal after tetrahydrofuran-based tissue clearing, referred to as 3D imaging of solvent-cleared organs (3DISCO).
Ann Rehabil Med, 2016 • October 1, 2016
This study developed an in vitro model of glial scarring that mimics the environment of a traumatically injured spinal cord using a combination of mechanical (scratch) and chemical (kainate) injuries....
KEY FINDING: Combining scratch injury with kainate treatment resulted in the most significant glial scarring, indicated by increased expression of GFAP, vimentin, CSPG, ROCK, and EphA4.
Stem Cell Rev and Rep, 2014 • May 8, 2014
This study investigates the guided migration of embryonic stem cell (ESC) derived presumptive motor neurons in an applied electric field (EF). The results showed that neural precursors migrated toward...
KEY FINDING: Neural precursors migrated toward the cathode pole of applied electric fields.
Clin. Pract., 2025 • December 26, 2024
Spinal cord injury (SCI) is defined as physical damage that alters the function and structure of the spinal cord. Traumatic causes, such as vehicle accidents, falls, and violence, account for 90% of S...
KEY FINDING: Early intensive care unit (ICU) monitoring improves patient prognosis, highlighting the importance of prompt ICU admission and early decompression surgery.
Exp Neurol, 2016 • September 1, 2016
The study examined whether eliminating myelin-associated inhibitors or activating intrinsic growth pathways could enhance NT-3-mediated regeneration of sensory axons through the dorsal root entry zone...
KEY FINDING: Loss of myelin inhibitory proteins showed modest enhancement of sensory axon regeneration.
International Medical Case Reports Journal, 2025 • January 4, 2025
This case report describes a 68-year-old male diagnosed with TTR-FAP with an uncommon presentation of spinal cord damage. The patient's symptoms included progressive limb weakness and numbness, autono...
KEY FINDING: The patient presented with a rare manifestation of TTR-FAP, specifically spinal cord damage, which is not commonly associated with the c.148G>A (p.Val50Met) mutation.