Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 5,161-5,170 of 5,253 results
Spinal Cord Series and Cases, 2016 • September 15, 2016
This case report highlights the diagnostic challenges in HIV-vacuolar myelopathy, emphasizing that a negative MRI scan does not exclude the condition. The importance of assessing both peripheral and c...
KEY FINDING: A negative or unspecific MRI scan does not rule out HIV-related myelopathy in HIV-positive patients with myelopathy symptoms.
Frontiers in Neuroscience, 2017 • August 8, 2017
This study investigated the safety and effects of HAL®-supported treadmill therapy on walking function in patients with limb-girdle muscular dystrophy (LGMD). Three LGMD patients underwent an 8-week t...
KEY FINDING: All patients completed the 8-week therapy without any adverse reactions and reported improvements in their endurance.
The Journal of Spinal Cord Medicine, 2017 • January 1, 2017
The study aimed to determine the inter-day reliability of blood pressure (brachial and finger) and cerebral blood flow velocity (CBFv) assessments in individuals with spinal cord injury (SCI) and able...
KEY FINDING: Brachial blood pressure assessment showed fair to substantial inter-day reliability.
Cells, 2021 • November 3, 2021
This review discusses recent advances in cell-based experimental strategies aimed at supporting or restoring function to the injured spinal cord, focusing on regenerative mechanisms relevant to clinic...
KEY FINDING: Transplantation of mesenchymal stem cells (MSCs) into the injured spinal cord can increase the number of M2 macrophages and reduce the number of M1 macrophages, leading to functional recovery in animal models.
Intensive Care Med, 2019 • October 28, 2019
The study addresses the absence of evidence-based algorithms for managing severe traumatic brain injury (sTBI) by developing a consensus-based algorithm for patients undergoing intracranial pressure (...
KEY FINDING: Consensus established 18 interventions as fundamental for sTBI care and ten treatments not to be used except in special circumstances.
Life, 2023 • December 20, 2022
Traumatic SCI induces complex pathological processes, leading to physical impairment and psychological devastation. The two phases are primary mechanical damage and secondary injury. This involves vas...
KEY FINDING: Neurotrophic factors like NGF, BDNF, and NT-3 are involved in the nervous system's development and maintenance, helping to rebalance the microenvironment after SCI. Mature NGF is neuroprotective, promoting neuronal differentiation and survival. BDNF has neuroprotective and growth-promoting effects, promoting regeneration and formation of damaged axons.
Neural Regen Res, 2020 • October 18, 2019
This study investigates the spatiotemporal expression of LIFR in normal and neural tube defect (NTD) embryos to understand its role in NTD pathogenesis. A rat model of spina bifida aperta (SBA) was us...
KEY FINDING: LIFR protein and mRNA expression in the spinal cords of normal rat embryos increased with embryonic development from E11 to E17.
Journal of Visualized Experiments, 2014 • November 25, 2014
The study presents an ex vivo laser-induced spinal cord injury (LiSCI) model for real-time assessment of axonal degeneration mechanisms. This model utilizes transgenic mice with fluorescently labeled ...
KEY FINDING: Laser-induced spinal cord injury (LiSCI) causes immediate axonal retraction and formation of sigmoidal-like coils within swollen myelin. Myelin ensheathing axons remote to the ablation appear unchanged at this time point.
Neural Regeneration Research, 2015 • December 1, 2015
TMS studies show increased motor cortex excitability after SCI, likely as a compensatory mechanism for impaired motor function. Various TMS techniques, such as SICI, MEP recruitment curves, and I-wave...
KEY FINDING: Motor cortex excitability is increased after spinal cord injury, as indicated by TMS studies. This suggests the brain attempts to compensate for impaired motor function.
J Neurosci Methods, 2016 • September 1, 2016
The study introduces a method to enhance FG uptake using Triton™, reducing FG-related tissue damage while maintaining effective quantification. Triton™ enhances FG uptake, reduces required FG, and sub...
KEY FINDING: Triton™ decreases the time required for long-distance transport of FG from the spinal cord to the motor cortex by >4 fold.