Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 5,171-5,180 of 5,253 results
J. Exp. Med., 2019 • November 4, 2019
This study investigates how neuronal circuits remodel after spinal cord injury, focusing on the role of neuronal activity in target selection during corticospinal tract (CST) rewiring. The researchers...
KEY FINDING: NMDAR signaling and CREB-mediated transcription are essential for maintaining nascent corticospinal tract (CST)–relay neuron contacts during circuit remodeling after spinal cord injury.
Clin Neurophysiol, 2014 • October 1, 2014
Persons with iSCI have fewer “building blocks” for constructing muscle activity, limiting the complexity of muscle coordination for overground walking. iSCI modules cannot explain the diversity of mus...
KEY FINDING: Motor module number, composition, and activation were significantly altered in persons with iSCI as compared to AB controls during overground walking at self-selected cadences.
Frontiers in Molecular Neuroscience, 2024 • July 15, 2024
This review summarizes recent advancements in understanding the roles of circRNAs in nerve injury and repair, focusing on their involvement in signaling pathways and gene regulatory networks pertinent...
KEY FINDING: CircRNAs play a role in peripheral nerve injury (PNI), with specific circRNAs like circ-Ankib1 and circ-Spidr influencing Schwann cell proliferation and axon regeneration.
Neural Regeneration Research, 2016 • August 1, 2016
This study used high-resolution aCGH to identify pathogenic CNVs in samples from patients with typical TCS. Our findings suggest an association between certain CNVs and nervous system disease. Ours st...
KEY FINDING: Array-based comparative genomic hybridization can be used to diagnose tethered spinal cord syndrome.
Exp Neurol, 2019 • August 1, 2019
The study investigated spinal reflex pathways coordinating antagonist muscles after peripheral nerve injury and muscle reinnervation in rats. The key finding was a severe dysregulation in mechanosenso...
KEY FINDING: Stretch applied to reinnervated antagonists produced much greater than normal levels in both suppression and facilitation of agonist muscle activity.
The Journal of Neuroscience, 1981 • July 1, 1981
The study demonstrates that the somatotopic mapping of medial dorsal horn cells in rats changes within 4-5 days after peripheral transection of afferents, leading to novel receptive fields. Afferents ...
KEY FINDING: Peripheral nerve transection leads to a reorganization of the spinal cord sensory map, with deafferented cells acquiring novel receptive fields on the thigh, lower back, or perineum.
JOURNAL OF NEUROTRAUMA, 2012 • August 10, 2012
The study evaluated the efficacy of dissociated predegenerated nerve (dPDN) transplants in promoting spinal cord regeneration and functional recovery in rats with spinal cord injuries, comparing them ...
KEY FINDING: dPDN grafts survive within the injured spinal cord and promote the ingrowth of axons to a similar extent as purified Schwann cell (SC) grafts.
International Journal of Nanomedicine, 2020 • January 1, 2020
The study investigated the interaction between MSCs and CP in a rat stroke model, finding that MSCs migrate to the CP and enhance its proliferation. MRI reveals MSC migration towards the CP in an isch...
KEY FINDING: ION-labeled MSCs migrate to the CP in an ischemic stroke model, as revealed by MRI and histological analysis.
The Journal of Neuroscience, 2007 • December 19, 2007
This study investigates the mechanisms underlying neuromuscular maps by studying the preferential outgrowth of embryonic spinal cord neurites on muscle membranes from different axial positions and exp...
KEY FINDING: Rostral cervical spinal cord neurites prefer to grow on rostral diaphragm membranes, while caudal cervical neurites prefer caudal diaphragm membranes.
J Korean Neurosurg Soc, 2014 • May 1, 2014
Autonomic dysreflexia is a clinical emergency in spinal cord injury patients that can lead to central nervous system complications, though rarely. This case reports a traumatic high level incomplete s...
KEY FINDING: A patient with a history of spinal cord injury developed right thalamic hemorrhage secondary to autonomic dysreflexia triggered by suprapubic catheter obstruction.