Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 5,181-5,190 of 5,253 results
PLoS ONE, 2019 • March 15, 2019
This study investigates how spinal cord injury (SCI) affects action anticipation by comparing SCI patients, physiotherapists (PHY), and rollerbladers (SKA) in predicting the outcomes of wheelchair and...
KEY FINDING: SCI participants performed better at anticipating actions involving wheelchairs, suggesting they developed expertise in this area after their injury.
Frontiers in Molecular Neuroscience, 2021 • March 22, 2021
The editorial discusses the dysfunction and repair of neural circuits for motor control, focusing on how trauma, neurodegenerative diseases, and pathological conditions affect these circuits. The Rese...
KEY FINDING: Motor cortical areas initiate communication with spinal cord circuitry for voluntary movement, conveying commands via spinal motor neurons to skeletal muscles; sensory information is equally essential.
The Journal of Spinal Cord Medicine, 2011 • April 1, 2011
This study reports on a series of eight patients who underwent nerve allograft transplantation for brachial plexus injuries. The goal was to assess the safety and efficacy of using cadaveric or living...
KEY FINDING: Seven out of eight patients showed signs of nerve regeneration after allograft transplantation, indicated by return of sensory and motor function or a migrating Tinel’s sign.
Frontiers in Cellular Neuroscience, 2015 • January 13, 2015
This study investigates spinal cord regeneration in Pleurodeles waltlii after complete transection, focusing on the role of neurogenesis and growth factors. It demonstrates that ependymal cells fill t...
KEY FINDING: Nestin expression is prominent in the rostral part of the spinal cord next to the lesion site one week after transection, implying neuronal progenitor migration to replace the missing tissue.
Scientific Reports, 2018 • January 9, 2018
This study investigated the feasibility of using a P300-based brain-computer interface (BCI) for communication in patients with Duchenne muscular dystrophy (DMD). Eight bedridden DMD patients and eigh...
KEY FINDING: The mean online accuracy of inputted characters was 71.6% for patients with DMD and 80.6% for controls, with no significant difference between the patients and controls.
EMBO reports, 2013 • August 9, 2013
The study investigates the role of STAT3 in corticospinal tract (CST) remodeling after spinal cord injury (SCI). It finds that sustained activation of STAT3 enhances remodeling of lesioned CST fibers ...
KEY FINDING: Endogenous STAT3 expression after spinal cord injury is transient and does not significantly contribute to axonal remodeling.
JoVE, 2011 • July 18, 2011
This protocol combines the DRG injury model with chromatin immunoprecipitation to investigate the transcriptional and epigenetic environment after injury to either the PNS or CNS. The ChIP protocol is...
KEY FINDING: The protocol demonstrates fragmented DNA to a length of approximately 200-1000 bp following sonication.
NEURAL REGENERATION RESEARCH, 2022 • October 1, 2022
This review discusses the critical roles of the mTOR pathway in axon regeneration in different types of CNS injury and demonstrates that the reactivation of this regenerative pathway can be achieved b...
KEY FINDING: mTOR signaling is the intrinsic axon regenerative pathway, and its reactivation can promote axon regeneration after adult CNS injury.
Neurology: Clinical Practice, 2019 • February 1, 2019
This study analyzes neurologic injuries sustained by patients in the Syrian war who were treated at a rehabilitation center on the Turkish-Syrian border from 2013 to 2016. The study found that gunshot...
KEY FINDING: Gunshot wounds were the dominant mechanism of injury in 54.3% of patients.
Cell Adhesion & Migration, 2009 • June 30, 2009
This study investigates the role of netrin-1 in sensory axonal guidance during development and regeneration. It reveals that netrin-1 functions as a chemorepellent for developing dorsal root ganglion ...
KEY FINDING: Netrin-1 acts as a chemorepellent for developing DRG axons, preventing them from projecting aberrantly toward the ventral spinal cord and ensuring correct projection toward the DREZ.