Neurology Research

KEY FINDING: The spinal injury scar comprises multiple cellular and extracellular components beyond just glial cells, including fibroblasts, immune cells, and extracellular matrix.

KEY FINDING: Temporally and spatially distinct changes in kallikrein expression were observed with partially overlapping patterns between human and murine SCI, including peak elevations (or reductions) during the acute and subacute periods.

KEY FINDING: Significant differences exist between the Midpoint and Otsu methods in quantifying intramuscular adipose tissue (%IntraMAT) in the knee extensor muscle group.

KEY FINDING: AxonTracer correlates strongly with semi-manual quantification by NeuronJ, a widely used ImageJ plugin, but with full automation and reduced user input.

KEY FINDING: A fecal management system (FMS) used to manage fecal incontinence triggered autonomic dysreflexia in a patient with tetraplegia.

KEY FINDING: Activation of the mTOR pathway can reduce neuronal death and promote repair and regeneration in the CNS.

KEY FINDING: OptoRaf or optoAKT activation enhanced axon regeneration in both regeneration-competent and -incompetent sensory neurons in the peripheral nervous system.

KEY FINDING: MHC-I upregulation peaks at 7 days postinjury in both C57BL/6J and A/J mice, but is significantly higher in the A/J strain.

KEY FINDING: Interneurons can combine into networks, shift the balance of neuronal activity, and select between pathways, with neuromodulators differentially affecting pathways.

KEY FINDING: Netrin-1 promotes significant regeneration of axonal tracts localized at the white matter segment across the transected area.