Browse the latest research summaries in the field of oncology for spinal cord injury patients and caregivers.
Showing 131-140 of 144 results
Genome Medicine, 2023 • February 15, 2023
This study investigated the tumor microenvironment (TME) remodeling in non-small cell lung cancer (NSCLC) patients after neoadjuvant PD-1 blockade combined with chemotherapy using single-cell RNA sequ...
KEY FINDING: Cancer cells from patients who responded well to treatment showed signs of presenting antigens, which helps the immune system recognize and attack them.
Signal Transduction and Targeted Therapy, 2020 • June 15, 2020
This letter identifies CBP-dependent DVL2 acetylation at K68 as a novel regulator in Wnt3a-induced DVL signalosome formation. DVL2-K68 acetylation is critical for activation of downstream β-catenin si...
KEY FINDING: CBP-dependent acetylation of DVL2 at K68 promotes DVL2 signalosome formation.
The EMBO Journal, 2023 • July 10, 2023
This study conducted single-cell RNA and TCR repertoire sequencing of primary CC tissues and adjacent normal tissues to decode the heterogeneity of the TME. The intra- and inter-tumoral heterogeneity ...
KEY FINDING: Cytotoxic large-clone T cells are critical effectors in the antitumor response.
Cureus, 2025 • January 16, 2025
This case highlights the vast diversity of pediatric spinal tumors and their potential for favorable postoperative outcomes. It also provides evidence for the existence of benign, fibrolipomatous infl...
KEY FINDING: The patient had an extensive extradural, intracanal mass from T1 to T10 causing spinal cord compression.
Neural Regen Res, 2018 • June 1, 2018
This study investigates the analgesic effect of AG490 on oxaliplatin-induced acute neuropathic pain in rats. The findings demonstrate that AG490 attenuates oxaliplatin-induced acute neuropathic pain b...
KEY FINDING: AG490 treatment significantly increased paw withdrawal threshold and tail withdrawal latency in rats with oxaliplatin-induced neuropathic pain, indicating reduced sensitivity to mechanical and cold stimuli.
Spinal Cord Series and Cases, 2019 • January 27, 2019
This case report describes a patient who presented with low back pain and was eventually diagnosed with solitary bone plasmacytoma (SBP) causing spinal cord compression. The patient underwent surgical...
KEY FINDING: The patient, initially presenting with low back pain, was diagnosed with solitary bone plasmacytoma (SBP) causing spinal cord compression at T7-T9, leading to incomplete paraplegia.
BioMed Research International, 2017 • July 25, 2017
This study analyzed the incidence, neurological function, and time trends of spinal cord injury (SCI) due to tumors or metastasis in Aragón, Spain, over an 18-year period (1991–2008). The incidence ra...
KEY FINDING: Tumors or metastasis accounted for 32.5% of nontraumatic SCI cases.
Leukemia, 2016 • January 29, 2016
This study by the European Research Initiative on CLL (ERIC) identified and validated a flow-cytometric approach to reliably quantitate CLL cells to the level of 0.0010% (10 −5). A parallel analysis o...
KEY FINDING: A six-marker flow cytometry panel (CD19, CD20, CD5, CD43, CD79b, and CD81) was identified as reliable and convenient for identifying typical CLL cells.
Biomolecules, 2022 • March 12, 2022
This study identifies three L1 antagonistic mimetics—anagrelide, 2-hydroxy-5-fluoropyrimidine, and mestranol—that inhibit the migration of cultured tumor cells in an L1-dependent manner. The mimetics ...
KEY FINDING: Anagrelide, 2-hydroxy-5-fluoropyrimidine, and mestranol competitively inhibit antibody 324 binding to L1, suggesting they interfere with L1's function.
Clinical and Molecular Hepatology, 2012 • September 1, 2012
This case report describes a 57-year-old man who developed paraplegia after undergoing TACE for costal metastasis of hepatocellular carcinoma. The patient presented with sudden sensory and motor funct...
KEY FINDING: A patient developed paraplegia following TACE targeting a costal metastasis of hepatocellular carcinoma.