Browse the latest research summaries in the field of oncology for spinal cord injury patients and caregivers.
Showing 71-80 of 144 results
Nano Res., 2021 • May 1, 2021
This review explores the bioengineering of nano metal-organic frameworks (nMOFs) for cancer immunotherapy, highlighting their potential to overcome limitations in current immunotherapy techniques. The...
KEY FINDING: nMOFs possess superior features over conventional nanocarriers, including high porosity, large surface area, greater tunability, accurate structure, and inherent superior functions without extra loading of functional agents.
Journal of Cancer, 2014 • September 20, 2014
This review discusses the role of fibroblasts in salamander limb regeneration and contrasts their activity with that of human fibroblasts in wound healing and cancer. It examines how the salamander's ...
KEY FINDING: Salamander regeneration can reverse tumorigenicity, as demonstrated by the reversion of frog tumor cells to normal tissues in regenerating limbs.
Acta Neurochirurgica, 2025 • January 19, 2025
This study retrospectively reviewed data from 72 patients who underwent surgery for spinal schwannomas to identify factors associated with residual neurological deficits. The study found that thoracic...
KEY FINDING: Thoracic spine involvement is a significant risk factor for residual neurological deficits after surgery (OR, 5.03; 95% CI, 1.47–18.6; p = 0.01).
Biomedicines, 2025 • February 12, 2025
This study investigates the effects of Ganoderic Acid DM (GA-DM), a natural extract from Ganoderma lucidum, on B-cell lymphoma. The research demonstrates that GA-DM exhibits anti-proliferative activit...
KEY FINDING: GA-DM induces apoptosis in human B-cell lymphoma cell lines DB and Toledo, and orchestrates autophagy and apoptosis in the murine B-cell lymphoma cell line A20.
OncoTargets and Therapy, 2020 • January 1, 2020
This study investigates the role of lncRNA LINC00691 in osteosarcoma. It demonstrates that LINC00691 expression is downregulated in osteosarcoma cells and tissues. The study reveals that LINC00691 fun...
KEY FINDING: LINC00691 expression is decreased in osteosarcoma cells compared to control cells.
Cell, 2023 • July 20, 2023
The study identifies Quaking proteins (QKIs) as mRNA internal m7G binding proteins. QKI7 shuttles internal m7G-modified mRNAs into stress granules (SGs) under stress conditions, regulating mRNA metabo...
KEY FINDING: QKIs preferentially recognize internal mRNA m7G modifications.
Scientific Reports, 2018 • August 7, 2018
The study successfully delivered IFN-α mRNA to human skin explants using biolistic application. Optimized IFN-α mRNA sequence variants resulted in significantly higher IFN-α protein expression compare...
KEY FINDING: Skin explants remained viable and intact for at least five days, making them suitable for testing.
Cell Proliferation, 2022 • January 2, 2022
This study identifies Toll-7 as a proto-oncogene in Drosophila that promotes tumor growth and invasion. Toll-7 activates Egr-JNK and EGFR-Ras signaling pathways, leading to cell proliferation, tissue ...
KEY FINDING: Loss of Toll-7 suppresses tumor growth and invasion in a Drosophila model of RasV12/lgl−/−-induced tumors.
Journal of Orthopaedic Surgery and Research, 2016 • January 1, 2016
This study evaluated the effects of x-ray irradiation on spinal cord regeneration in rats after injury. Rats were subjected to spinal cord injury and then treated with either 10 Gy or 20 Gy of x-ray i...
KEY FINDING: NF counts were higher in both 10-Gy and 20-Gy irradiated groups compared to the sham group at both 6 and 14 weeks after SCI, suggesting that x-ray treatment might promote the regeneration of the spinal cord central nervous system.
J Hematol Oncol, 2020 • October 13, 2020
This study identifies MNPC, a dual inhibitor of NQO1 and GSTP1, as a potential therapeutic agent for glioblastoma (GBM). MNPC selectively inhibits the proliferation of GBM cells bearing the EGFRvIII m...
KEY FINDING: MNPC is a small molecule inhibitor that binds to both NQO1 and GSTP1 with high affinity and selectivity, inhibiting their enzymatic activities.