Browse the latest research summaries in the field of oncology for spinal cord injury patients and caregivers.
Showing 61-70 of 144 results
Am J Cancer Res, 2015 • November 1, 2015
This study investigates the crosstalk between p53 and TGF-beta signaling in neural progenitor cells (NPC) derived from p53 mutant mice, focusing on the impact on cell proliferation and growth arrest. ...
KEY FINDING: NPC derived from p53 mutant mice exhibit increased clonogenicity and a more rapid proliferation rate compared to their wildtype counterparts.
Nat Med, 2017 • March 1, 2017
This study provides a comprehensive assessment of epigenetic heterogeneity in Ewing sarcoma, highlighting the importance of non-genetic aspects in tumor heterogeneity. The research performed genome-sc...
KEY FINDING: Ewing sarcoma tumors displayed consistent DNA hypomethylation at enhancers regulated by the EWS-FLI1 fusion protein, indicating epigenomic enhancer reprogramming.
ONCOLOGY LETTERS, 2017 • January 1, 2017
The study investigates the expression profile of ING3 protein in both normal and cancerous tissues of mice and humans, using immunohistochemistry to determine its location within cells. Results indica...
KEY FINDING: ING3 protein is widely distributed in normal mouse tissues, particularly in the cytoplasm of cardiomyocytes, kidney, and skeletal muscle cells.
Biotechnology Reports, 2018 • January 1, 2018
This study explores the use of the Proseek Single-Plex Protein Assay Kit System for detecting sAxl and Gas6 in HGG patients' blood, aiming for more sensitive detection than standard ELISA methods. The...
KEY FINDING: The Proseek method demonstrates higher sensitivity in detecting lower concentrations of Gas6 compared to the DuoSet sandwich ELISA method.
ONCOLOGY LETTERS, 2019 • January 1, 2019
The study characterized the expression profile of ING5 protein in normal mouse and human tissues, and human cancer tissues. ING5 expression was primarily detected in the cytoplasm of normal mouse and ...
KEY FINDING: ING5 expression varies in different tissues, with cytoplasmic localization being more common in normal mouse and human tissues.
Neurotherapeutics, 2019 • March 6, 2019
This study investigated the efficacy of a double-targeted GMCSF-NgR-PirB nucleic acid vaccine as an immunotherapy strategy for spinal cord injury (SCI) in rats. The vaccine was designed to stimulate t...
KEY FINDING: The GMCSF-NgR-PirB nucleic acid vaccine stimulated the production of antibodies against NgR and PirB in rats.
Med Sci Monit, 2019 • June 24, 2019
This study evaluated prognostic factors for overall survival (OS) and cause-specific survival (CSS) in patients with non-metastatic osteosarcoma using the SEER database. Multivariable analysis identif...
KEY FINDING: Age, tumor size, grade, and AJCC T staging were independent prognostic factors for OS and CSS.
OncoTargets and Therapy, 2019 • December 1, 2019
This study investigates the role of miR-26a-5p in osteosarcoma cells and finds that it is highly expressed in osteosarcoma cell lines compared to noncancerous cells, suggesting its involvement in oste...
KEY FINDING: miR-26a-5p is highly expressed in osteosarcoma cell lines compared to noncancerous cells, especially in U2OS cells.
AGING, 2020 • May 19, 2020
The study aimed to identify piRNAs with abnormal expression in PTC that could serve as biomarkers for early detection. Using Next Generation Sequencing (NGS) and RT-qPCR, piR-13643 and piR-21238 were ...
KEY FINDING: piR-13643 and piR-21238 were significantly upregulated in PTC tissues compared to non-cancerous tissues.
Redox Biology, 2020 • May 21, 2020
This study investigates how glioblastoma (GBM) cells cope with high levels of reactive oxygen species (ROS). The researchers found that C/EBPβ, a transcription factor, regulates the expression of NQO1...
KEY FINDING: C/EBPβ is highly expressed in GBM tumors and correlates with poor patient survival rates.