Browse the latest research summaries in the field of orthopedics for spinal cord injury patients and caregivers.
Showing 251-260 of 352 results
Diagnostics, 2018 • August 24, 2018
This study investigates the potential of contrast-enhanced ultrasound (CEUS) and cytokine expression analysis (CEA) to predict the outcome of non-union therapy in tibial non-unions. The results sugges...
KEY FINDING: Lower TNF-α expression before surgery was associated with a positive response to non-union therapy.
Regen. Med., 2018 • October 22, 2018
The study aimed to determine the bone regenerative potential of a cellular allograft uniquely processed from UCB to optimize high MNC count and to enrich cytokine content. The UCBp-CM elevated prolife...
KEY FINDING: UCBp-CM elevated proliferation and migration rates of mesenchymal stem cells (MSCs) and bone marrow stromal cells.
International Journal of Molecular Sciences, 2019 • January 14, 2019
The review focuses on the biological properties of CaP/BG composite bone substitutes, summarizing recent experimental data to understand their osteogenic properties. BGs have limitations such as poor ...
KEY FINDING: BGs enhance osteogenic differentiation of precursor cells in vitro when added to CaPs, suggesting a synergistic effect.
International Journal of Molecular Sciences, 2019 • February 2, 2019
This study investigated the use of zonal chondrocyte/mesenchymal progenitor cell constructs in minipigs for the treatment of focal cartilage defects, comparing them to non-zonal grafts and empty contr...
KEY FINDING: Both zonal and non-zonal constructs showed a significantly increased bone loss in the defects when compared to controls, suggesting an osteolytic effect of PCL-enforced implants on the subchondral bone.
Cells, 2019 • April 30, 2019
The study investigated the transcriptome-wide responses of Il-1β-primed rat Achilles tendon cell-derived 3D tendon-like constructs to high-energy PEMF treatment. RNASeq analysis revealed various biolo...
KEY FINDING: PEMF exposure of Il-1β-treated 3D tendon-like constructs resulted in a change in the expression pattern of approximately 5400 genes.
Med Sci Monit, 2019 • June 24, 2019
This study evaluated prognostic factors for overall survival (OS) and cause-specific survival (CSS) in patients with non-metastatic osteosarcoma using the SEER database. Multivariable analysis identif...
KEY FINDING: Age, tumor size, grade, and AJCC T staging were independent prognostic factors for OS and CSS.
Journal of Orthopaedic Research, 2020 • October 4, 2019
This study aimed to identify circulating microRNAs (miRNAs) associated with chronic rotator cuff tendinopathy and degenerative rotator cuff tears (RCTs) to determine their potential as diagnostic tool...
KEY FINDING: Six miRNAs (hsa-miR-19b-3p, hsa-miR-192-5p, hsa-miR-25-3p, hsa-miR-19a-3p, hsa-miR-18b-5p, hsa-miR-93-5p) were exclusively repressed in patients with degenerative RCTs compared to controls and chronic tendinopathy.
International Journal of Surgery Case Reports, 2020 • December 12, 2019
This case report presents the successful treatment of a vertebral body defect (VBD) in a 27-year-old female using umbilical cord-derived mesenchymal stem cells (UC-MSCs) combined with hydroxyapatite s...
KEY FINDING: The patient could walk and had no pain three months post-surgery.
EBioMedicine, 2020 • January 1, 2020
The study aimed to investigate the regenerative effects of transplanting bone marrow-derived mesenchymal stem cells (BMSCs) embedded in ultra-purified alginate (UPAL) gel on degenerated intervertebral ...
KEY FINDING: Co-culturing nucleus pulposus cells (NPCs) and bone marrow-derived mesenchymal stem cells (BMSCs) in UPAL gel significantly increased the expression of NPC markers, growth factors, and extracellular matrix genes compared to monocultures.
Scientific Reports, 2021 • January 11, 2021
This study aimed to assess whether UPAL gel implantation reduces inflammatory cytokine levels, prevents intervertebral disc degeneration, and reduces acute pain after discectomy in rat and rabbit disc...
KEY FINDING: UPAL gel implantation suppressed TNF-α and IL-6 production in both rat and rabbit models of discectomy.