Browse the latest research summaries in the field of orthopedics for spinal cord injury patients and caregivers.
Showing 341-350 of 352 results
BioMed Research International, 2016 • October 17, 2016
This study investigated the spatiotemporal changes of CGRP during spinal fusion to explore its role in bone regeneration. The results demonstrated that the early stage of normal spinal fusion is accom...
KEY FINDING: The density of CGRP reached its peak on the 21st day after the spinal fusion surgery in rats.
Materials Today Bio, 2024 • February 22, 2024
This study introduces an injectable nanocomposite hydrogel (OGPGM) composed of PGA-Mn nanoparticles, oxidized sodium alginate, and gelatin for treating osteoarthritis (OA). OGPGM exhibits excellent bi...
KEY FINDING: The nanocomposite hydrogel (OGPGM) exhibits excellent biocompatibility, effectively removes ROS from chondrocytes, and reduces inflammatory factors within the joint.
Journal of Athletic Training, 2012 • October 1, 2012
This study developed a cadaveric neck model to simulate head-first impacts in sports and investigate biomechanical responses and failure mechanisms. The research found that local compression force pea...
KEY FINDING: The first compression force peaks at the impact barrier, occipital condyles, and neck occur earlier than global compression peaks.
Gene, 2011 • July 1, 2011
The study demonstrates that miR-146a regulates cartilage-degrading proteases and pain-associated inflammatory molecules in knee joint tissues. MiR-146a functions in an anti-catabolic manner by antagon...
KEY FINDING: MiR-146a suppresses extracellular matrix proteins in human knee chondrocytes and regulates inflammatory cytokines in human knee joint synovial cells.
Cureus, 2023 • July 31, 2023
Diagnosis of low back pain combines old and new methodologies, in particular, it involves an expanded role for ultrasound. Tumors and infections are rarely involved in low back pain but should be rule...
KEY FINDING: Autologous blood products like platelet-rich plasma are safe and effective in stimulating the body’s regenerative responses for musculoskeletal pain.
Journal of Orthopaedic Surgery and Research, 2018 • September 28, 2018
This study explored the use of serum chemokine analysis to predict outcomes in non-union patients undergoing Masquelet therapy. The research identified CCL-3 and IFN-γ as potential biomarkers that, wh...
KEY FINDING: CCL-3 expression was significantly higher in non-responders (NR) compared to responders (R) during the study course (p = 0.002).
Arch Phys Med Rehabil, 2016 • June 1, 2016
This article addresses issues related to the availability and choice for surgery, preoperative assessments, postoperative training paradigms, and appropriate outcome measures for upper extremity recon...
KEY FINDING: Specific guidelines for postoperative training paradigms after upper limb reconstructive surgery in tetraplegia are not readily available.
Spinal Cord Series and Cases, 2018 • January 3, 2018
This case report describes a rare instance of central cord syndrome (CCS) in a young, previously healthy novice surfer following a surfing accident. The patient presented with acute tetraplegia and se...
KEY FINDING: A 35-year-old novice surfer presented with acute tetraplegia and sensory deficits after a surfing accident.
Frontiers in Surgery, 2023 • September 11, 2023
Failed fracture healing remains a significant complication, and ongoing research aims to improve understanding of contributing factors at local and systemic levels. The immune system's role in bone he...
KEY FINDING: Interferon-gamma (IFN-y) signaling plays a key role in orchestrating immunological functions and serves an anabolic function in osseous biology, leading to osteoblastic activation.
Journal of Inflammation Research, 2021 • January 1, 2021
This study aimed to determine the incidence of occult infections (OI) in patients receiving autologous bone grafting (ABG) for non-union (NU) treatment, evaluate its impact on the outcome, and identif...
KEY FINDING: The incidence of occult infections after non-union treatment of the lower limb remains at 9.04% despite thorough preoperative screening.