Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 11-20 of 555 results
PLoS ONE, 2023 • May 2, 2023
This cross-sectional prospective study will explore the previously understudied hypothesis that SRBDs are associated with increased neuropathic pain, spasticity, and cardiovascular autonomic dysfuncti...
KEY FINDING: Individuals with SCI and untreated SRBDs will develop more intense neuropathic pain.
Pain Ther, 2023 • April 28, 2023
This multinational, open-label study assessed the long-term safety and efficacy of mirogabalin for central neuropathic pain (CNeP) in Asian patients with spinal cord injury (CNePSCI), Parkinson's dise...
KEY FINDING: Mirogabalin was generally safe and well-tolerated, with common side effects including somnolence, peripheral edema, edema, and dizziness, most of which were mild.
Trials, 2023 • June 5, 2023
This study protocol outlines a prospective, single-center, open-label, randomized, two-way crossover trial to investigate the efficacy of differential target multiplexed (DTM) spinal cord stimulation ...
KEY FINDING: The primary outcome will be the rate of pain improvement, defined as a 33% or greater reduction in pain scores, three months after SCS system implantation.
Journal of Inflammation Research, 2023 • June 13, 2023
This review highlights the significant role of non-coding RNAs (ncRNAs) in regulating neuroinflammation (NI) following spinal cord injury (SCI), which subsequently influences the development of neurop...
KEY FINDING: miRNAs regulate inflammation after SCI by influencing microglia-mediated inflammation, with some miRNAs like miR-137-3p reducing pro-inflammatory factors by targeting NeuroD1. NF-κB-dependent inflammation is also modulated by miRNAs, impacting neuropathic nociceptive hyperalgesia.
J Pain, 2023 • November 1, 2023
The study aimed to identify variables that moderate treatment response to four psychological pain interventions: cognitive therapy (CT), hypnosis (HYP), hypnosis focused on changing pain-related cogni...
KEY FINDING: Higher hypnotizability was associated with better outcomes in depressive symptoms for those who received hypnosis and hypnotic cognitive therapy.
The Journal of Spinal Cord Medicine, 2024 • May 31, 2023
This systematic review assessed the efficacy of various strategies for treating pain interference in individuals with neuropathic pain following spinal cord injury. Moderate to high quality studies sh...
KEY FINDING: Pregabalin and gabapentin were shown to have a beneficial effect on sleep interference.
The Journal of Spinal Cord Medicine, 2024 • January 1, 2024
The study assessed the occurrence and characteristics of neuropathic pain in 104 patients with traumatic spinal cord injury (SCI). The results indicated that 74% of patients experienced neuropathic pa...
KEY FINDING: Neuropathic pain was present in 74% of the spinal cord injury patients studied.
J. Clin. Med., 2023 • July 7, 2023
This case study describes the adaptation and implementation of hypnotic cognitive therapy (HYP-CT) intervention for early SCI pain in the context of mechanical ventilation dependence and weaning. The ...
KEY FINDING: The participant reported immediate reductions in pain intensity following each intervention session.
Int. J. Mol. Sci., 2023 • July 5, 2023
This research evaluates the feasibility of a multimodal pain assessment protocol during rehabilitation following spinal cord injury (SCI). The protocol amalgamates clinical workup (CW), quantitative s...
KEY FINDING: The SCI Pain Instrument (SCIPI) was efficient in distinguishing between nociceptive and neuropathic pain, showing a progressive increase in severity over time.
Journal of Traditional Chinese Medicine, 2023 • December 14, 2022
This study aimed to investigate the analgesic effects of Chinese Tuina on neuropathic pain in rats by examining synaptic structure remodeling in the spinal cord dorsal horn (SCDH). The results showed ...
KEY FINDING: Tuina and MK-801 (an NR2B antagonist) reversed CCI-induced changes in motor function and reduced mechanical and cold allodynia in rats.