Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 91-100 of 555 results
Archives of Rehabilitation Research and Clinical Translation, 2024 • January 1, 2024
This case report investigates the effectiveness of cryoneurolysis for pain and spasticity in a patient with spinal cord injury, severe orthopedic deformity, and impaired hand function. Percutaneous cr...
KEY FINDING: Cryoneurolysis led to immediate and sustained improvements in ROM in both upper and lower limbs.
Scientific Reports, 2025 • January 13, 2025
This study explores the protective effect of prior exercise against neuropathic pain (NP) in rats by examining protein expression changes in the spinal dorsal horn using proteomic analysis. The findin...
KEY FINDING: Prior exercise significantly increased the mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) in rats with CCI, indicating a reduction in pain sensitivity.
Journal of Medical Case Reports, 2025 • January 8, 2025
This case report describes the successful insertion of a new intrathecal baclofen catheter in a patient with a fractured catheter, without removing the original fractured catheter. The new catheter wa...
KEY FINDING: The intrathecal baclofen catheter breakage was identified as the cause of the patient's worsening spasticity 13 years after the initial pump implantation.
HRB Open Research, 2024 • September 2, 2024
This study protocol outlines a phase 2 randomized trial to assess exoskeleton walking for neuropathic pain after spinal cord injury. The trial aims to address the need for non-pharmacological treatmen...
KEY FINDING: The study will assess recruitment and retention rates for an exoskeleton-based walking intervention.
Cellular and Molecular Neurobiology, 2025 • January 12, 2025
This study investigates changes in neuronal activation along the sensory neuroaxis in a rat model of spinal cord injury (SCI) exhibiting below-level pain. The findings reveal that SCI amplifies the en...
KEY FINDING: Spinal cord injury (SCI) amplifies the activation of dorsal horn (DH) neurons in a stimulus-dependent manner, primarily after noxious stimulation.
Neurochemical Research, 2025 • January 16, 2025
This study investigates the mechanisms underlying neuropathic pain (NP), focusing on the role of mTOR in astrocytes. It finds that mTOR is activated in astrocytes following chronic constriction injury...
KEY FINDING: mTOR is activated in astrocytes within the spinal cord following chronic constriction injury (CCI), contributing to neuropathic pain.
Clinical Case Reports, 2025 • January 1, 2025
This case report presents a 60-year-old male with a cervical spinal cord injury (SCI) who experienced significant improvements in motor function, spasticity, and pain after receiving spinal cord stimu...
KEY FINDING: The patient experienced a 60% improvement in spasticity and a 50% improvement in mobility of his right upper extremity following SCS.
Healthcare, 2025 • January 26, 2025
This study investigates the relationship between Pressure Pain Threshold (PPT) and various clinical, cognitive, and motor factors in Spinal Cord Injury (SCI) patients. It uses a cross-sectional analys...
KEY FINDING: Incomplete SCI lesions are linked to increased pain sensitivity (lower PPT), suggesting altered neural processing exacerbates pain responses.
PLOS ONE, 2025 • February 27, 2025
This study investigated the role of anoikis-related genes in neuropathic pain (NP), particularly in lumbar disc herniation (LDH). Machine learning algorithms identified six key genes (HGF, MMP13, ABL1...
KEY FINDING: Six key anoikis-related genes (HGF, MMP13, ABL1, ELANE, FASN, and LINC00324) were identified as having diagnostic value for NP.
Cureus, 2025 • February 22, 2025
This case report discusses the effective use of spinal cord stimulation (SCS) to treat lower limb pain caused by conus medullaris syndrome. This case highlights the diagnostic difficulties associated ...
KEY FINDING: The patient experienced electric shock-like pain during epidural anesthesia for laparoscopic colon resection, which persisted postoperatively, leading to the diagnosis of conus medullaris syndrome.