Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 101-110 of 555 results
The Journal of Spinal Cord Medicine, 2022 • April 1, 2022
Chronic pain after spinal cord injury significantly affects quality of life, necessitating a shift towards non-opioid treatments due to the opioid crisis. The review highlights antiepileptic and antid...
KEY FINDING: Antiepileptic drugs like pregabalin and gabapentin have demonstrated efficacy in managing chronic SCI-related neuropathic pain.
The Journal of Spinal Cord Medicine, 2021 • July 1, 2021
This study examined the relationships between physical activity (PA) levels and the secondary conditions of chronic pain and fatigue in individuals with spinal cord injury (SCI) using a mobile health ...
KEY FINDING: Light-intensity PA showed a positive linear relationship with task-specific pain, indicating that as light activity increases, task-specific pain may also increase.
The Journal of Spinal Cord Medicine, 2021 • July 1, 2020
This pilot study aimed to identify differences in resting cerebral blood flow between individuals with spinal cord injury (SCI)-related neuropathic pain (NP) and healthy controls using arterial spin l...
KEY FINDING: Individuals with SCI-related neuropathic pain exhibited significantly reduced resting blood flow in the cerebellum (specifically Crus I/II), the rostral ventromedial medulla, and the left insular cortex compared to healthy controls.
The Journal of Spinal Cord Medicine, 2022 • January 1, 2022
This scoping review examined the existing research on the effect of cannabis on pain intensity in individuals with spinal cord injury (SCI). The review found that the current evidence is insufficient ...
KEY FINDING: The review identified six articles covering five treatment studies, but the findings were mixed due to variations in methodology.
Cureus, 2021 • June 1, 2021
This case report describes a rare instance of spinal cord injury (SCI) following thoracic radiofrequency ablation (RFA). The patient, a 37-year-old male, developed paresthesias, weakness, and urinary ...
KEY FINDING: The patient experienced paresthesias below the nipple line and progressive lower-extremity weakness within one week of the procedure.
The Journal of Spinal Cord Medicine, 2023 • January 1, 2023
This study investigated the efficacy of FES cycling for pain reduction in patients with SCI. The results showed significant improvements in pain scores, quality of life, and neurophysiological measure...
KEY FINDING: Statistically significant changes were found in pain-NRS, MPI-SCI, and SF-36 scores, and LEP amplitudes, indicating a reduction in pain and improved quality of life following FES cycling.
Current Neuropharmacology, 2022 • January 1, 2022
This review summarizes current knowledge about four epigenetic modifications—DNA/RNA methylation, histone acetylation, and circRNAs—in chronic pain. Epigenetic modifications may shed lights on the chr...
KEY FINDING: DNA methylation, mediated by enzymes like DNMTs and TETs, plays a role in chronic pain development. Specifically, the upregulation of methyltransferase DNMT3a is widely involved in chronic pain induced by a variety of causes, and it promotes the occurrence and development of chronic pain by inhibiting the transcription of analgesic-related genes by increasing the methylation level of these genes.
International Journal of Environmental Research and Public Health, 2021 • August 25, 2021
This pilot study investigated the immediate effect of VR in reducing neuropathic pain (NP) in people with spinal cord injury (SCI). Eight individuals with chronic NP after SCI underwent consecutive ex...
KEY FINDING: Short-term exposure to both scenery and somatic VR environments resulted in a significant reduction in neuropathic pain intensity in people with spinal cord injury.
BIOENGINEERED, 2021 • August 4, 2021
This study investigates the role of circSMEK1 in neuropathic pain (NP) using rat and cell models. The results indicate that circSMEK1 and TXNIP are upregulated in NP, while miR-216a-5p is downregulate...
KEY FINDING: CircSMEK1 and TXNIP are upregulated in neuropathic pain (NP), while miR-216a-5p is downregulated.
Brain Sciences, 2021 • September 12, 2021
Neuropathic pain following spinal cord injuries is difficult to treat. VR offers an alternative by providing illusory or reality-like experiences. VR modulates body ownership and agency, increasing pa...
KEY FINDING: VR can modulate the sense of ownership of the whole body or single body parts by altering the congruity of multisensory information.