Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 341-350 of 555 results
The Journal of Spinal Cord Medicine, 2018 • January 1, 2018
This letter to the editor discusses the feasibility of remotely supervised tDCS for neuropathic pain in a person with spinal cord injury. The study involved training the participant and their caretake...
KEY FINDING: Remotely supervised tDCS is feasible for individuals with SCI and neuropathic pain.
Toxins, 2018 • June 1, 2018
This review examines the mechanism of central neuropathic pain and assesses the effect of BTX on central neuropathic pain. The review summarizes the mechanism of central neuropathic pain and botulinum...
KEY FINDING: BTX inhibits the secretion of substance P and CGRP from dorsal root ganglion (DRG) neurons, reduces the expression of TRPV1 and P2X3 receptors, and induces a central effect through retrograde axonal transport, all of which contribute to its potential analgesic effects.
Molecular Pain, 2018 • June 8, 2018
This study investigates the therapeutic potential of Pak1 inhibition for pain associated with cutaneous burn injury using romidepsin, an FDA-approved inhibitor. The findings demonstrate that Pak1 inhi...
KEY FINDING: Inhibition of Pak1 by romidepsin decreased dendritic spine dysgenesis in the dorsal horn of mice with burn injury.
Aust Occup Ther J, 2018 • October 1, 2018
The study examined the measurement properties of the BPI interference scale for measuring pain interference in persons with SCI. Rasch analysis was used to evaluate the dimensionality of the BPI inter...
KEY FINDING: Four of the original seven BPI interference items provide acceptable measurements of pain interference in the SCI population.
Medicine, 2018 • August 3, 2018
This pilot study retrospectively investigated the feasible effect and safety of neuromuscular electrical stimulation (NMES) for the management of neuropathic pain (NPP) caused by spinal cord injury (S...
KEY FINDING: NMES did not reduce pain intensity of NPP, measured by the NRS, compared with cases in the control group.
Spinal Cord Series and Cases, 2018 • May 13, 2018
This perspective argues against the use of opioids for chronic pain after spinal cord injury (SCI), highlighting the lack of evidence for their effectiveness and the significant risks associated with ...
KEY FINDING: There is a lack of evidence supporting the long-term effectiveness of opioids for treating pain after SCI, except for one small study supporting the effectiveness of tramadol in the short term.
Spinal Cord Series and Cases, 2018 • June 7, 2018
The author argues that cannabis is an effective pain reliever for individuals with spinal cord injuries and should be more accessible for both patients and researchers. The paper highlights the histor...
KEY FINDING: Patients with SCI and chronic pain report cannabis as the single most effective medication out of 26 pain treatments.
JOURNAL OF NEUROTRAUMA, 2019 • March 15, 2019
This study investigates the immunomodulatory effects of exercise on neuropathic pain development after spinal cord injury (SCI) in rats. The research reveals that rats with SCI-induced neuropathic pai...
KEY FINDING: Rats with SCI-induced neuropathic pain exhibited greater microglial activation in the dorsal horn compared to rats without pain. Exercise reduced this activation.
Journal of Pain Research, 2018 • January 1, 2018
This study explored the modulation of chronic neuropathic pain (NP) following spinal cord injury (SCI) using breathing-controlled electrical stimulation (BreEStim) and measured changes in heart rate v...
KEY FINDING: SCI+NP subjects had lower baseline HRV compared to SCI–NP subjects.
Anesthesiology, 2019 • February 1, 2019
This study demonstrates that morphine administration following a tibial fracture in mice exacerbates nociceptive sensitization and functional impairment, prolonging recovery. The adverse effects of mo...
KEY FINDING: Morphine treatment after tibial fracture exacerbates mechanical nociceptive sensitization and prolongs its duration.