Pain Management Research

KEY FINDING: Repetitive SCS further increases many existing upregulated immune responses in chronic constrictive injury rats, including transcription of cell surface receptors and activation of non-neuronal cells.

KEY FINDING: Both high (10 kHz) and lower frequencies (200 Hz, 500 Hz, 1200 Hz) of subthreshold SCS attenuated mechanical hypersensitivity in nerve-injured rats.

KEY FINDING: Repeated social defeat (RSD) stress increases mechanical allodynia (pain sensitivity) in mice.

KEY FINDING: Conventional SCS may be more effective for reducing pain in patients with incomplete SCI, particularly those with lesions at low thoracic to upper lumbar levels.

KEY FINDING: Neural stem cell transplantation markedly increased neurofilament protein expression in the injured spinal cord segment 4 weeks post-transplantation.

KEY FINDING: DTT scans revealed narrowing of the spinothalamic tract (STT) in both hemispheres of both patients.

KEY FINDING: Most spinal cord medicine clinicians employ a multimodal approach to pain, indicating that individualized and multimodal strategies are common.

KEY FINDING: There was no initial correlation between responses to tonic heat and neuropathic pain severity upon admission to rehabilitation.

KEY FINDING: Stretching-induced drops in locomotor function were observed in nociceptor-intact animals but were nearly absent in nociceptor-depleted animals.

KEY FINDING: MCS shows a positive effect on refractory pain, with a total percentage improvement of 35.2% in post-stroke pain and 46.5% in trigeminal neuropathic pain.