Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 141-150 of 525 results
Spinal Cord Series and Cases, 2017 • June 8, 2017
This case report presents a 27-year-old male with a T10 ASIA Impairment Scale A spinal cord injury who developed hyperphosphatemia as a complication of etidronate therapy for heterotopic ossification....
KEY FINDING: A patient with SCI developed hyperphosphatemia during etidronate treatment for HO.
J Mol Neurosci, 2008 • November 1, 2008
Vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) are expressed in the neural pathways regulating the lower urinary tract. VIP-immunoreactivity (IR...
KEY FINDING: Exogenously applied VIP relaxes bladder and urethral smooth muscle and excites parasympathetic neurons in bladder ganglia.
Epitomes-Physical Medicine and Rehabilitation, 1974 • August 1, 1974
The pharmacologic management of severe spasticity has continued to be relatively ineffective, even since the introduction of the so-called 'muscle relaxants'. A peripherally acting skeletal muscle rel...
KEY FINDING: Dantrolene sodium is more effective than diazepam in the treatment of spasticity.
J Spinal Cord Med, 2008 • January 1, 2008
The study evaluated the efficacy and safety of sildenafil in men with erectile dysfunction (ED) associated with spinal cord injury (SCI). Sildenafil was found to be superior to placebo in improving er...
KEY FINDING: Sildenafil significantly improved successful sexual stimulation and intercourse rates compared to placebo in men with ED and SCI.
Int. J. Mol. Sci., 2024 • December 11, 2024
Nanotechnology has emerged as a transformative force in neuroscience, addressing challenges that have long impeded progress in the diagnosis and treatment of CNS disorders. Theranostic NPs stand out a...
KEY FINDING: Nanoparticles can be engineered to cross the blood-brain barrier (BBB) using passive targeting, active targeting, and stimuli-responsive systems, enhancing drug delivery to the CNS.
Brain, 2010 • January 1, 2010
This study investigated the effects of long-term baclofen use on the contractile properties of paralyzed motor units in individuals with cervical spinal cord injury. The results indicated that baclofe...
KEY FINDING: Long-term baclofen use and paralysis resulted in significantly weaker motor unit tetanic forces compared to uninjured subjects.
Arch Phys Med Rehabil, 2010 • May 1, 2010
This review supports the use of anticonvulsants such as gabapentin or pregabalin for post-SCI neuropathic pain. Tricyclic antidepressants were supported by limited evidence in those patients with supe...
KEY FINDING: Gabapentin and pregabalin, anticonvulsant medications, have strong evidence for effectiveness in treating neuropathic pain post-SCI.
Cochrane Database of Systematic Reviews, 2010 • May 1, 2010
This Cochrane review assessed pharmacological interventions for acute heterotopic ossification. The review has been withdrawn from publication. Withdrawal was due to the review being out-of-date and t...
KEY FINDING: The review was withdrawn due to being substantially out-of-date.
Journal of Visualized Experiments, 2011 • April 18, 2011
This video demonstration highlights methods to assess changes in reflex activity, volitional strength and ambulation following the acute oral administration of SSRIs in human SCI. This battery of asse...
KEY FINDING: Following oral administration of SSRI in an individual with motor incomplete SCI there are notable alterations in clinical measures of motor activity.
JOURNAL OF NEUROTRAUMA, 2012 • March 20, 2012
This study evaluated the effects of D-AMPH administration, skilled forelimb training, and EE housing in rats with unilateral cervical contusion injuries to see if this combination of treatments would ...
KEY FINDING: AMPH combined with skilled forelimb motor training improved qualitative reaching in rats with cervical SCI compared to controls and drug-only groups.