Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 521-525 of 525 results
Biomedicines, 2021 • July 8, 2021
This study evaluated the efficiency of a cationic, hyperbranched poly(amidoamine)s-based nanoparticle system to deliver tdTomato mRNA to primary human bone marrow stromal cells (hBMSC), human synovial...
KEY FINDING: Transfection efficiencies varied among the cell types tested (bCH 28.4% ± 22.87, rTDSPC 18.13% ± 12.07, hBMSC 18.23% ± 14.80, hSDSC 26.63% ± 8.81).
British Journal of Pharmacology, 2018 • January 1, 2018
This study investigates the analgesic effects of ASP3662, a novel 11β-HSD1 inhibitor, in rat models of neuropathic and dysfunctional pain. ASP3662 is a potent, selective, and CNS-penetrable inhibitor ...
KEY FINDING: ASP3662 effectively inhibits 11β-HSD1 in humans, mice, and rats, demonstrating selectivity over 11β-HSD2 and showing no significant impact on other enzymes, transporters, and receptors.
Drug Discov Today, 2012 • August 1, 2012
This review provides an overview of traumatic CNS injuries and discusses emerging pharmacological options, highlighting therapies that modulate mTOR signaling. The mTOR pathway plays an important role...
KEY FINDING: Activation of the mTOR pathway can reduce neuronal death and promote repair and regeneration in the CNS.
Journal of Nanobiotechnology, 2025 • January 22, 2025
This study engineered a methylprednisolone substitution lipid nanoparticle (MP-LNP) encapsulating C3 transferase mRNA (MP-LNP-C3) for SCI treatment. The MP-LNP effectively transfected neurons and achi...
KEY FINDING: The incorporation of C3 transferase mRNA into MP-LNPs does not compromise the structural integrity of the nanoparticles, ensuring efficient mRNA expression within the spinal cord.
Advanced Science, 2024 • September 28, 2024
This study demonstrates that traumatic pathological vascular remodeling occurs during the chronic phase of injury, characterized by enlarged vessel diameter, disruption of blood-spinal cord barrier, e...
KEY FINDING: Traumatic SCI leads to pathological vascular remodeling, including enlarged vessel diameter and disruption of the blood-spinal cord barrier.