Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 131-140 of 525 results
Drug Design, Development and Therapy, 2020 • December 4, 2020
This study investigates the effect of sanguinarine (SG) on chronic constriction injury (CCI)-induced neuropathic pain (NP) in rats. SG is a natural plant medicine known for its anti-inflammatory and n...
KEY FINDING: Sanguinarine (SG) treatment increased paw withdrawal mechanical threshold (PWT) and thermal withdrawal latency (TWL) in CCI rats, indicating reduced mechanical sensitivity and heat hypersensitivity.
ASSAY and Drug Development Technologies, 2015 • September 1, 2015
The study developed two HCA assays to investigate reactive-like changes in astrocytes: one measuring the stellation index (GFAP+ process area/cell body area) and another monitoring the expression of g...
KEY FINDING: The GFAP morphology assay is suitable for counter-screening with a Z-factor of 0.44 – 0.03.
CNS Drug Reviews, 2004 • January 1, 2004
4-Aminopyridine (4-AP or fampridine) is a potassium channel-blocking agent that has been shown to restore conduction in focally demyelinated axons. The present review summarizes the relevant pharmacol...
KEY FINDING: 4-AP has been shown to restore conduction in focally demyelinated axons by blocking potassium channels.
TheScientificWorldJOURNAL, 2006 • February 17, 2006
The objective of this article was to determine the current practice on amikacin dosing and monitoring in spinal cord injury patients from spinal cord physicians and experts. This study shows that ther...
KEY FINDING: Clinical practice varies considerably across spinal units regarding amikacin administration, with some using once-daily dosing and others using divided doses.
Molecular Pain, 2006 • April 3, 2006
The study investigated the role of PKC in spinal cord in mediating chronic injury-induced pain and its relationship with glutamate receptors. Activation of PKC in the spinal cord produces mechanical h...
KEY FINDING: Intrathecal injection of PDBu (phorbol 12,13 dibutyrate) decreased the mechanical withdrawal threshold bilaterally in a dose-dependent manner, indicating increased sensitivity to pain.
Spinal Cord Series and Cases, 2017 • May 11, 2017
This case report describes the successful use of ceftolozane/tazobactam (C/T) to treat a febrile urinary tract infection (UTI) caused by multidrug-resistant (MDR) Pseudomonas aeruginosa (PSA) in a 35-...
KEY FINDING: Ceftolozane/tazobactam was effective in treating a febrile UTI caused by multidrug-resistant Pseudomonas aeruginosa in a patient with a neurogenic bladder.
J Spinal Cord Med, 2006 • January 1, 2006
This case report describes a 33-year-old man with refractory spasticity who experienced acute intrathecal baclofen (ITB) toxicity leading to deep coma within minutes of drug administration. The patien...
KEY FINDING: The patient developed respiratory difficulty, a generalized seizure, and coma minutes after ITB administration.
J Spinal Cord Med, 2006 • January 1, 2006
This study evaluated the effectiveness and adverse effects of a single 90-mg pamidronate dose in patients with acute SCI compared to a 30 mg/d 3 3-day regimen. The results showed that the single dose ...
KEY FINDING: Single-dose pamidronate 90 mg is effective at reducing biochemical markers of bone hyperresorption in patients with acute SCI but is associated with a greater incidence of fever compared with a 30 mg/d 3 3-day dosing regimen.
Spinal Cord Series and Cases, 2017 • May 18, 2017
This correspondence critically evaluates a study comparing amitriptyline and lamotrigine for neuropathic pain after spinal cord injury. The authors highlight the scarcity of direct comparisons between...
KEY FINDING: The original study by Agarwal and Joshi reports the effectiveness of amitriptyline and lamotrigine in neuropathic pain after traumatic spinal cord injuries.
Neurosci Lett, 2007 • June 8, 2007
This study investigated the role of spinal metabotropic glutamate receptors (mGluRs) in the control of lower urinary tract functions in rats. The results suggest that group I/II mGluRs are likely invo...
KEY FINDING: In spinal cord intact rats, blocking group I/II mGluRs with MCPG facilitated EUS EMG activity at a dose of 100 μg.