Pharmacology Research

KEY FINDING: Early surgical decompression (within 24 hours) is associated with better neurological recovery and shorter hospital stays.

KEY FINDING: Oral AZD1390 significantly suppresses pATM levels in dorsal root ganglia (DRG) at 4 weeks after DC injury.

KEY FINDING: SCI's physiopathology is an extremely disabling disease that heavily affects the life of the patients and is the result of a primary injury that is then followed by a secondary one, commonly known as the main cause of post-traumatic neural degeneration.

KEY FINDING: Tandospirone (TDS) ameliorated visceral hypersensitivity and anxiety-like behavior induced by water avoidance stress.

KEY FINDING: G-CSF generally downregulates neurogenic differentiation markers in most brain regions studied.

KEY FINDING: DrSim outperforms existing methods in drug annotation, showing higher accuracy in predicting the mechanisms of action (MOAs) of compounds.

KEY FINDING: Andro treatment significantly improved tissue repair and functional recovery after SCI by reducing apoptosis, oxidative stress, and inflammation through the Nrf-2/HO-1 and NF-κB signaling pathways.

KEY FINDING: RSV exhibits anti-inflammatory effects by inhibiting pro-inflammatory cytokines like IL-1β, IL-6, IL-8, and TNF-α, which ameliorates IDD progression mediated by inflammation.

KEY FINDING: Knockdown or peptide inhibition of RTN4R, the gene encoding the RTN4/NoGo-Receptor, lowers ataxin-2 protein levels in mouse and human neurons in vitro.

KEY FINDING: AST-FC combined therapy effectively alleviated oxidative stress and the inflammatory response in the acute phase of BPA.