Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 191-200 of 525 results
Frontiers in Pharmacology, 2022 • January 10, 2022
Recombinant adenoviruses (rAdVs) are commonly used vectors in gene therapy for spinal cord injury (SCI) due to their ability to transduce various cell types and provide high transgene expression. The ...
KEY FINDING: rAdV5-based vectors allow transduction of both nerve and glial cells, providing a high level of transgene expression.
Adv Healthc Mater, 2022 • May 1, 2022
The study addresses the thermal instability of ChABC, which limits its therapeutic use for CNS injuries. Machine learning was used to design copolymers that stabilize ChABC in aCSF, with promising res...
KEY FINDING: Active machine learning identified copolymers that significantly improved ChABC's thermal stability.
Scientific Reports, 2022 • January 28, 2022
The study establishes a motor nerve organoid model from human pluripotent stem cells to investigate axonal degeneration and regeneration under oxidative stress conditions. The model demonstrates that ...
KEY FINDING: Motor nerve organoids derived from human pluripotent stem cells (hPSCs) can be efficiently generated and exhibit characteristics of mature motor neurons.
Scientific Reports, 2022 • February 18, 2022
The study demonstrates that phentolamine treatment enhances functional recovery after peripheral nerve injury (PNI) in mice. This includes improved motor function, protection of axon myelination, and ...
KEY FINDING: Phentolamine treatment significantly enhanced functional recovery in mice at 14 days post-injury (dpi) following peripheral nerve injury, as evidenced by improved rotarod performance and sciatic function index (SFI).
Biomolecules, 2022 • February 23, 2022
This review discusses the potential role of leukotriene signaling in the pathogenesis of Parkinson's disease (PD) and dementia with Lewy bodies (DLB), highlighting the involvement of leukotrienes in n...
KEY FINDING: Dysregulated leukotriene signaling is implicated in the pathological processes of Parkinson's disease (PD) and dementia with Lewy bodies (DLB), suggesting a potential therapeutic target.
Nanomaterials, 2022 • March 30, 2022
This review highlights the potential of lipid-based nanomaterials in addressing bone complications, particularly bone metastasis, by offering targeted drug delivery and improved therapeutic efficacy. ...
KEY FINDING: Lipid-based nanocarriers can be modified with bisphosphonates to enhance their affinity for bone, allowing for improved drug delivery to targeted areas within the bone structure.
Frontiers in Pharmacology, 2022 • March 31, 2022
This study investigated the therapeutic potential of SHED-CM for neuropathic pain (NP) using a mouse model of partial sciatic nerve ligation (PSL). The results showed that SHED-CM effectively reduced ...
KEY FINDING: Intravenous administration of SHED-CM greatly improved PSL-induced hypersensitivity, indicating a reduction in neuropathic pain symptoms in mice.
Exp Neurol, 2022 • September 1, 2022
This study investigates a therapeutic strategy co-targeting kinases involved in extrinsic and intrinsic regulatory pathways to promote axon regeneration after spinal cord injury (SCI). The kinase inhi...
KEY FINDING: RO48 promotes neurite growth from various neuronal types in vitro, including hippocampal, cortical, sensory, and human iPSC-derived glutamatergic neurons.
Biotechnology Advances, 2022 • May 16, 2022
Extracellular vesicles (EVs), particularly exosomes, hold promise for treating various diseases and promoting tissue regeneration. However, current production methods suffer from low yield and scalabi...
KEY FINDING: Mechanical loading, such as shear stress or cyclic tension, can significantly increase EV secretion, potentially by over 100-fold.
Pharmaceuticals, 2022 • April 25, 2022
This study investigates the regulatory action of miR-182-5p on Nogo-A, a myelin-associated inhibitor of axonal regeneration. The research demonstrates that miR-182-5p downregulates Nogo-A protein expr...
KEY FINDING: miR-182-5p mimic specifically downregulates the expression of the luciferase reporter gene fused to the mouse Nogo-A 3′UTR, and Nogo-A protein expression in Neuro-2a and C6 cells.