Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 221-230 of 525 results
Bioactive Materials, 2023 • April 2, 2023
This review provides a comprehensive overview of microneedle systems, including potential cargos, structural designs, material selection, and drug release mechanisms. The review summarizes different m...
KEY FINDING: Microneedles can easily pass through physical barriers at wound sites and sustainably release drugs, enhancing drug delivery efficiency.
CNS Neuroscience & Therapeutics, 2023 • January 1, 2023
The study aimed to characterize gecko thrombin (gthrombin) due to the rapid coagulation and scarless regeneration observed in geckos after tail amputation, seeking a safe and efficient blood clotting ...
KEY FINDING: Recombinant gthrombin showed super-high catalytic and fibrinogenolytic efficiency compared to human thrombin under various temperature and pH conditions.
Pharmaceutics, 2023 • May 21, 2023
This study investigates the therapeutic potential of Roflumilast (Rof), a PDE4 inhibitor, in a rat model of thoracic spinal cord injury (SCI). The findings demonstrate that Rof treatment promotes funct...
KEY FINDING: Roflumilast treatment promoted functional recovery in rats with spinal cord injuries, enabling them to support their weight and take occasional steps, as measured by the BBB score.
Nanoscale Advances, 2023 • May 5, 2023
The study optimized PLGA-based nanoparticles for delivering miRNA-129-5p to modulate activated microglia. Nanoformulations PLGA-miR+Sp and PLGA-miR+PEI showed significant immunomodulatory effects, sus...
KEY FINDING: PLGA-miR+Sp and PLGA-miR+PEI formulations were found to be significant in their immunomodulatory effects compared to naked PLGA-based NPs.
Frontiers in Pharmacology, 2023 • July 18, 2023
This study provides a comprehensive analysis of the current research status and frontiers of stem cell therapy for spinal cord injury using bibliometric methods. It identifies key contributors, popula...
KEY FINDING: The study found that research on stem cell therapy for spinal cord injury has been increasing since 2000. Neural Regeneration Research was the journal with the most publications and the fastest cumulative publication growth.
Metabolites, 2023 • August 3, 2023
The study investigates the efficacy of combining a ketogenic diet (KD), metformin (MET), and metronomic cyclophosphamide (CP) as a triple therapy for MYCN-amplified neuroblastoma (NB). Results showed ...
KEY FINDING: MET reduces cell proliferation and mitochondrial respiration in MYCN-amplified NB cell lines.
Journal of Neuroimmune Pharmacology, 2023 • September 2, 2023
This study found that aOECs could attenuate inflammatory response by regulating microglia from pro-inflammatory to anti-inflammatory phenotype in SCI rats, thus facilitating functional recovery. The s...
KEY FINDING: CCM-activated OECs effectively attenuated deleterious inflammation by regulating microglia polarization from the pro-inflammatory (M1) to anti-inflammatory (M2) phenotype in SCI rats and facilitated functional recovery after SCI.
Gels, 2023 • November 16, 2023
Natural, synthetic, and composite injectable hydrogels can all be used as delivery systems to encapsulate stem cells, drugs, or GFs for a wide range of applications in SCI therapy. The mechanisms by w...
KEY FINDING: Natural hydrogels are efficient scaffolds for functional recovery and drug/cell delivery after SCI.
The Journal of Neuroscience, 2024 • February 7, 2024
This study investigates the role of HCN ion channels in opioid-induced hyperalgesia (OIH) and opioid-induced tolerance (OIT). The research demonstrates that OIH is driven by HCN2 ion channels in perip...
KEY FINDING: Peripheral HCN2 ion channels drive opioid-induced hyperalgesia (OIH). Blocking or genetically deleting HCN2 in primary nociceptive neurons abolishes OIH.
Nature Communications, 2015 • October 27, 2015
The present work demonstrates that the anti-asthmatic drug and leukotriene receptor antagonist montelukast restores learning and memory function in old rats. Montelukast treatment reduced age-associat...
KEY FINDING: Montelukast treatment significantly improved task learning in old rats to a level comparable to young ones.